Assisted Reproductive Technology (ART) Predictors Study

Status:Enrolling by invitation
Age Range:18 - 44
Start Date:September 2009
End Date:December 2016

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Novel Predictors of ART Outcomes

The goals of this research proposal are to further our understanding of the reproductive
aging process in women and to improve our ability to clinically assess and model
reproductive aging. Reproductive aging is a continuous process that begins many years prior
to menopause. Women in their late 30s and early 40s usually maintain normal menstrual
function and ovulatory status, yet fertility in these women is considerably compromised
compared to younger women. The primary mechanism of reproductive aging is through the
process of ovarian primordial follicle (egg) depletion, a process that exhibits considerable
variation between women. As a result, the age at which an individual begins to experience
infertility and menstrual cycle changes secondary to follicle depletion also varies
significantly and is difficult to predict. The clinical assessment of the number of
primordial follicles remaining in the ovary has traditionally relied upon the measurement of
ovarian or pituitary hormones such as FSH, estradiol, and inhibin B. Unfortunately, these
measures are all indirect and poorly sensitive in the assessment of ovarian reserve. More
recently, serum levels of anti-Müllerian hormone (AMH) and the ovarian antral follicle count
have been utilized as clinical measures of ovarian reserve. Both have been correlated with
chronological age and have some predictive power in determining stimulation quantity (the
number of oocytes obtained at the time of egg-recovery) in in-vitro fertilization (IVF)
treatment cycles. Reproductive aging in women; however, is more than just the depletion of
oocytes from a woman's ovaries, but also involves a decline in oocyte quality. The
predictive value of these clinical markers of ovarian reserve with regards to oocyte quality
is unknown. Additionally, new tools developed to assess biological aging in other organ
systems such as white blood cell telomere length and the measurement of advanced glycation
end products (AGEs) through skin autofluorescence have not been evaluated with respect to
the reproductive aging process. This proposal seeks to develop better models of normal
female reproductive aging by identifying novel markers of ovarian reserve and determining
their relationship with both oocyte quantity and quality obtained during IVF treatment

To test our hypotheses, we will enroll 120 healthy women undergoing ART cycles at OU
Physicians Reproductive Health.

Patients undergoing an ART treatment cycle at the OU Physicians Reproductive Health clinic
will be approached regarding enrollment.

- informed consent

- collection of baseline demographic data (height, weight, ethnicity, age)

- cycle-day 3 measurements of FSH, estradiol, inhibin B, AMH, white-blood cells for
telomere length assay, and measurement of hemoglobin A1C to control for blood glucose

- AFC as determined by transvaginal ultrasound exam

- skin autofluorescence measurement

- subjects then undergo IVF as directed by their physician

- outcome measures include number of oocytes recovered, peak estradiol, quantity of
gonadotropins utilized during the course of treatment, and assessment of oocyte quality
by morphology assessment with light microscopy.

Inclusion Criteria:

- Undergoing an ART treatment cycle

- Age range 18-44 years old

- NOTE: Must be willing to travel to Oklahoma City to participate. Need to have
the transvaginal ultrasound and skin autofluorescence measurement at the OU
Physicians Reproductive Health Clinic in Oklahoma City, Oklahoma

- NOTE: Study will not pay for ART/IVF treatment.

Exclusion Criteria:

- Gynecological malignancy

- chemotherapy or radiation therapy treatment

- Autoimmune disease

- Prior ovarian surgery

- Ovarian pathology
We found this trial at
940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
Oklahoma City, OK
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