A Single-Dose Open-Label of XOMA 358 in Patients With Hypoglycemia After Gastric Bypass Surgery

Inclusion Criteria:

- Aged at least 18 years of age

- Weight ≥ 60 kg and ≤ 120 kg and Body Mass Index < 35 kg/m2 at baseline

- Received gastric bypass surgery more than 1 year before dosing

- Occurrence of postprandial hypoglycemia during the baseline period assessments

Exclusion Criteria:

- History of type 1 diabetes

- Planned use of the following medications on or after Day -3:

- Any agent for hypoglycemia, such as diazoxide or octreotide

- Antihyperglycemic agents, including subcutaneous insulin therapy, sulfonylureas,
SGLT2 inhibitors, and GLP-1 agonists

- Systemic glucocorticoids or β agonists that may affect glucose metabolism

- Long-acting somatostatin analogs or glucose-affecting medications

- Major general surgery within 3 months before study entry or anticipated during the
study period

Other protocol-defined inclusion/exclusion criteria may apply