A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures



Status:Terminated
Conditions:Neurology, Epilepsy
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:16 - 75
Updated:7/13/2018
Start Date:August 2008
End Date:February 2010

Use our guide to learn which trials are right for you!

An International, Double-blind, Randomized, Multi-center, Parallel Group, Historical-control Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures With or Without Secondary Generalization

Antiepileptic drugs (AEDs) are the main treatment for epilepsy; however, only a limited
number of AEDs are approved for use as monotherapy. The objective of this study is to
evaluate the efficacy of Brivaracetam (BRV) in the conversion of partial onset seizure
patients from combination treatment to monotherapy


Inclusion Criteria:

- Subjects from 16 to 75 years, both inclusive

- Well-characterized focal epilepsy or epileptic syndrome

- Subjects having at least 2 but not exceeding 40 partial onset seizures, whether or not
secondarily generalized per 4 weeks during the 8-week Baseline Period

- Subjects on a stable dose of at least 1 but no more than 2 concomitant Antiepileptic
Drugs (AEDs) with the second AED ≤ 50 % of the minimum recommended maintenance dose

Exclusion Criteria:

- Seizure type IA non-motor as only seizure type

- History or presence of seizures occurring too frequently or indistinctly separated to
be reliably counted during the 6 months preceding Visit 1 or during Baseline

- Other serious uncontrolled disease
We found this trial at
27
sites
180
mi
from 02139
Bronx, NY
Click here to add this to my saved trials
1695
mi
from 02139
Austin, TX
Click here to add this to my saved trials
10
mi
from 02139
Burlington, MA
Click here to add this to my saved trials
Charleston, West Virginia 25304
620
mi
from 02139
Charleston, WV
Click here to add this to my saved trials
10087
mi
from 02139
Chatswood,
Click here to add this to my saved trials
926
mi
from 02139
Conyers, GA
Click here to add this to my saved trials
1546
mi
from 02139
Dallas, TX
Click here to add this to my saved trials
597
mi
from 02139
Danville, VA
Click here to add this to my saved trials
1763
mi
from 02139
Denver, CO
Click here to add this to my saved trials
2590
mi
from 02139
Fresno, CA
Click here to add this to my saved trials
1123
mi
from 02139
Germantown, TN
Click here to add this to my saved trials
712
mi
from 02139
Hickory, NC
Click here to add this to my saved trials
1601
mi
from 02139
Houston, TX
Click here to add this to my saved trials
704
mi
from 02139
Kettering, OH
Click here to add this to my saved trials
2377
mi
from 02139
Las Vegas, NV
Click here to add this to my saved trials
766
mi
from 02139
Lexington, KY
Click here to add this to my saved trials
946
mi
from 02139
Macon, GA
Click here to add this to my saved trials
1256
mi
from 02139
Miami, FL
Click here to add this to my saved trials
172
mi
from 02139
Mineola, NY
Click here to add this to my saved trials
180
mi
from 02139
New York, NY
Click here to add this to my saved trials
1490
mi
from 02139
Oklahoma City, OK
Click here to add this to my saved trials
1112
mi
from 02139
Orlando, FL
Click here to add this to my saved trials
2580
mi
from 02139
Pasadena, CA
Click here to add this to my saved trials
960
mi
from 02139
Peoria, IL
Click here to add this to my saved trials
2292
mi
from 02139
Phoenix, AZ
Click here to add this to my saved trials
203
mi
from 02139
Summit, NJ
Click here to add this to my saved trials
869
mi
from 02139
Waukesha, WI
Click here to add this to my saved trials