Radiation-Free Heart Catheterization Using MRI



Status:Recruiting
Conditions:Cardiology, Cardiology, Cardiology, Cardiology, Cardiology, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:Any
Updated:7/26/2018
Start Date:March 2015
End Date:December 2023
Contact:Joshua Kanter, MD
Email:jkanter@childrensnational.org
Phone:202-476-2020

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Currently catheters used in heart catheterization procedures are guided throughout the heart
chambers and blood vessels by pictures taken by x-rays. This technology exposes patients to
radiation. With this study protocol the investigators will use MRI technology to take
real-time pictures to navigate catheters throughout heart chambers. MRI uses electromagnetic
energy; therefore, it does not expose participants to radiation energy.

Participants undergo general anesthesia, and vascular access is obtained in the x-ray
catheterization lab. Next the participant is transferred into the MRI scanner where a focused
MRI examination is performed. Catheters are then guided into the heart chambers using
real-time MRI guidance to perform conventional cardiac catheterization steps. If time allows,
additional research MRI is performed before the participant is returned to the x-ray
catheterization lab. If any MRI guided catheterization steps are unsuccessful, the clinically
indicated step is performed after the participant returns to the x-ray catheterization lab
using conventional x-ray guided pictures.

Inclusion Criteria:

- Undergoing a medically necessary cardiovascular catheterization

Exclusion Criteria:

- Cardiovascular instability including hemodynamic instability (such as requiring
significant vasoactive infusion support) or mechanical hemodynamic support.

- Women who are pregnant

- Women who are nursing and who do not plan to discard breast milk for 24 hours

- Patients with a contraindication to MRI scanning will be excluded. These
contraindications include patients with the following devices:

1. Central nervous system aneurysm clips

2. Implanted neural stimulator

3. Implanted cardiac pacemaker or defibrillator which are not MR safe or MR
conditional according to the manufacturer

4. Cochlear implant

5. Ocular foreign body (e.g. metal shavings)

6. Implanted Insulin pump

7. Metal shrapnel or bullet

Exclusion criteria for Gadolinium (contrast agent)

1. Renal disease with estimated glomerular filtration rate < 30 ml/min/1.73 m2 body surface
area
We found this trial at
1
site
Washington, District of Columbia 20010
Principal Investigator: Joshua Kanter, MD
Phone: 202-476-2020
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mi
from
Washington,
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