Bone Health in Patients With Overgrowth
| Status: | Recruiting |
|---|---|
| Conditions: | Orthopedic, Women's Studies |
| Therapuetic Areas: | Orthopedics / Podiatry, Reproductive |
| Healthy: | No |
| Age Range: | 5 - Any |
| Updated: | 1/11/2019 |
| Start Date: | September 2015 |
| End Date: | December 2020 |
| Contact: | Henry Nguyen, MD |
| Email: | Nguyen.Henry@mayo.edu |
The goal of this study is to determine whether or not patients with overgrowth syndromes have
decreased bone density.
decreased bone density.
It is known that patients with complex vascular malformation are at risk of decreased bone
density and even vanishing bone disease. However, what is not known is if patients with OGS
are at decreased bone density at locations that are distant from the vascular malformation.
This study will look at bone health in patient's with OGS in a cross sectional fashion. If
they are found to be at a particular risk for decreased bone density then this can be
addressed in early childhood, through nutrition and activity recommendations.
The study will consist of 15 participants, all who have a known clinical diagnosis of an
overgrowth syndrome, and will be >5 years old so that they can co operate with a DEXA or
Xtreme CT scan.
Study specifics:
- They will be asked specific questions regarding medical and family history and an intake
form will be filled out.
- The height, weight, body mass index and Tanner stage measurements will be recorded
during this visit.
- Photos of the affected area(s) will be taken, however, this is optional.
- A urine pregnancy test will be done in all females of childbearing potential .
- Laboratory studies will be performed in all patients.
- A 24-hour urine sample will be collected from adults who are able and willing; in
children and in those not able or unwilling to provide a 24-hour urine, a spot urine
will be collected.
- Bone age will be assessed via plain film of the wrist
- Bone density will be assessed for each patient via DEXA scan
- Cortical and trabecular parameters and bone strength will be assessed by HRpQCT
density and even vanishing bone disease. However, what is not known is if patients with OGS
are at decreased bone density at locations that are distant from the vascular malformation.
This study will look at bone health in patient's with OGS in a cross sectional fashion. If
they are found to be at a particular risk for decreased bone density then this can be
addressed in early childhood, through nutrition and activity recommendations.
The study will consist of 15 participants, all who have a known clinical diagnosis of an
overgrowth syndrome, and will be >5 years old so that they can co operate with a DEXA or
Xtreme CT scan.
Study specifics:
- They will be asked specific questions regarding medical and family history and an intake
form will be filled out.
- The height, weight, body mass index and Tanner stage measurements will be recorded
during this visit.
- Photos of the affected area(s) will be taken, however, this is optional.
- A urine pregnancy test will be done in all females of childbearing potential .
- Laboratory studies will be performed in all patients.
- A 24-hour urine sample will be collected from adults who are able and willing; in
children and in those not able or unwilling to provide a 24-hour urine, a spot urine
will be collected.
- Bone age will be assessed via plain film of the wrist
- Bone density will be assessed for each patient via DEXA scan
- Cortical and trabecular parameters and bone strength will be assessed by HRpQCT
Inclusion Criteria:
- Age > 5 years such that the patient is able to cooperate with the DXA scan or Xtreme
CT
- Known clinical diagnosis of an overgrowth syndrome such as Klippel-Trenaunay Syndrome,
CLOVE syndrome, Proteus syndrome, diffuse capillary malformation with overgrowth, or
other unspecified OGS.
Exclusion Criteria:
- Age < 5 years
- Inability to comply with the scan
- No or uncertain diagnosis of an OGS.
- Prior bisphosphonate use
- Systemic steroids in the past 6 months
- Pregnant women
We found this trial at
1
site
Click here to add this to my saved trials
