PP-Gemcitabine & External Beam Radiation-Sarcomas

Before the start of treatment, participants will have a physical exam, blood tests, a MRI
scan, and a chest x-ray. A PET scan may be done if thought necessary.

Participants will receive the drug gemcitabine by vein along with radiation therapy on Days
1, 8, 22, 29, 43, and 50. Radiation treatments will be given 5 days a week for 5 weeks. The
gemcitabine and radiotherapy will be given on an outpatient basis. Chemotherapy and/or
radiotherapy may be stopped if side effects become severe.

About 4 to 6 weeks after the final dose of gemcitabine, surgery will be done to remove the
tumor or to remove any previous surgical scar and leftover tumor.

During the combined treatment, participants will be seen weekly by the doctor in charge of
radiotherapy or by the study nurse. Blood tests will be done every week during treatment. A
MRI scan and a chest x-ray will be done within 14 days before surgery. A PET scan will be
done if thought necessary.

After the surgery is done, participants will return to M. D. Anderson for follow-up visits
every 4 months for the first 2 years, every 6 months for 3 years, and then yearly from then
on. An ultrasound and MRI scan (of the extremity or trunk) will be done 3 months after
completion of all treatment. Ultrasound scans will be performed at each visit. A MRI scan
will only be done again at later visits if needed.

This is an investigational study. Gemcitabine is approved for use by the FDA. Its use
together with radiation therapy in this study is experimental. About 36 individuals will
take part in the study. All will be enrolled at M. D. Anderson.

Inclusion Criteria:

1. Patients with cytologic or histologic proof of Grade II or III resectable soft tissue
sarcoma of the extremity or trunk.

2. Patients with both measurable and non-measurable disease. Patients who are S/P
pre-referral excision will be eligible.

3. Inclusion of patients with a prior history of malignancy will be at the discretion of
the Study Chairman.

4. Patients must have a Zubrod Point Scale of 0 or 1.

5. Absolute neutrophil count must be > 1,500 cells/mm; platelet count greater than or
equal to 100,000 platelets/ml; serum creatinine less than or equal to 1.8 mg/dl,
serum glutamate oxaloacetate transaminase (SGOT)/serum glutamate pyruvate
transaminase (SGPT) less than or equal to 3 x normal, total bilirubin less then or
equal to 1.5 mg/dl.

6. Patients must have no uncontrolled coexisting medical conditions.

7. Women of childbearing potential must not be pregnant or breast feeding and must
practice adequate contraception.

8. All patients must sign an informed consent.

Exclusion Criteria:

1) Patients with a history of prior radiotherapy in the area of the primary tumor or those
in whom the anticipated radiation field would include the perineum, scrotum, or vaginal
introitus will not be eligible.