An Extension Study of ABT-199 in Subjects With Advanced Non-Hodgkin's Lymphoma



Status:Active, not recruiting
Conditions:Lymphoma, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 99
Updated:10/11/2018
Start Date:December 20, 2013
End Date:June 19, 2019

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An Extension Study of Venetoclax in Subjects With Advanced Non-Hodgkin's Lymphoma

This is a Phase 1, open-label, multicenter, extension study. Subjects with non-Hodgkin's
lymphoma (NHL) (excluding chronic lymphocytic lymphoma [CLL], small lymphocytic lymphoma
[SLL], and mantle cell lymphoma [MCL]) who completed a prior ABT-199 study, or were active
and assigned to ABT-199 when the study was completed, may roll over into this extension
study. Subjects will receive ABT-199 during this study.


Inclusion Criteria:

- Subject has completed a prior ABT-199 study (and had met the criteria for a diagnosis
of NHL and all other eligibility criteria for the previous study) and the investigator
believes that treatment with ABT-199 is in the best interest of the subject.

Exclusion Criteria:

- Subject discontinued ABT-199 administration before completing the prior study (due to
disease progression, toxicity, withdrawn consent, other).

- Subject has any medical condition that in the opinion of the investigator places the
subject at an unacceptably high risk for toxicities.

- Subject has not recovered to ≤ Grade 2 clinically significant adverse
effect(s)/toxicity(ies) of previous therapy.

- Subject has been diagnosed with Post-Transplant Lymphoproliferative Disease (PTLD),
Burkitt's lymphoma, Burkitt-like lymphoma, lymphoblastic lymphoma/leukemia, chronic
lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or mantle cell lymphoma
(MCL).
We found this trial at
3
sites
Hackensack, New Jersey 07601
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Hackensack, NJ
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Lebanon, New Hampshire 03756
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Lebanon, NH
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1501 North Campbell Avenue
Tucson, Arizona 85724
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Tucson, AZ
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