Effect of 10-day Overnight Hypoxia Treatment on Whole Body Insulin Sensitivity (SLEEP HIGH Study)
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | July 2011 |
| End Date: | May 2013 |
The purpose of this study is to look at how a reduction in oxygen levels (hypoxia)
influences insulin sensitivity and carbohydrate metabolism. It is expected that 10 nights of
exposure to moderate hypoxia (~ 15% O2, similar to conditions at an altitude of ~7500 feet)
will improve glucose metabolism.
influences insulin sensitivity and carbohydrate metabolism. It is expected that 10 nights of
exposure to moderate hypoxia (~ 15% O2, similar to conditions at an altitude of ~7500 feet)
will improve glucose metabolism.
Inclusion Criteria:
- Aged 20-45 years
- Male
- Obese category (BMI > 30 kg/m2)
- Healthy as assessed by a self-reported health questionnaire
- Non-smokers
- Weight stable over the past 3 months (<2kg fluctuation)
Exclusion Criteria:
- Female
- Diabetes
- Sleep apnea
- Hypertension
- History of altitude sickness
- Individuals taking any chronic medications
- Individuals taking any stimulants
- Individuals taking beta-blockers
- Individuals with chronic alcohol consumption (>3 drinks per day) or drug abuse.
- Individuals unable to abstain from caffeinated beverage or alcohol the days of study
testing
- Individuals with history disease or history of stroke
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