Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Conditions:Psychiatric, Women's Studies, Pain, Urology
Therapuetic Areas:Musculoskeletal, Nephrology / Urology, Psychiatry / Psychology, Reproductive
Age Range:Any
Start Date:January 15, 2007
End Date:December 31, 2021
Contact:Elicia Estrella, MS, LCGC

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Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a condition with several causes
of which some remain unknown. It is believed that some types of CP may be genetic or passed
down (inherited) from one generation to the next.

In this study, we are collecting genetic material and medical information to try to determine
if there are genetic factors may play a role in CP/CPPS. We will be collecting DNA (from a
Saliva sample) and urine from each participant. Individuals and families with CP/CPPS will be
enrolled. Family members of an individual with CP/CPPS are eligible whether or not they also
experience CP/CPPS symptoms.

We would like to determine if chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has
a genetic cause. We will be attempting to further describe the symptoms of CP/CPPS and to
correlate them with changes in your genes. We will use several types of genetic testing;
linkage analysis, whole exome sequencing and candidate gene studies. Each individual
participant will be required to give a DNA sample (via Saliva), a urine sample and answer 2
questionnaires. All samples will be stored. Travel to Boston NOT required.

Inclusion Criteria:

- Have symptoms for at least 3 months within the preceding 6 months:

- Pain in the pelvic area

- Urinary frequency and/or

- Urinary urgency and/or

- Sexual dysfunction (erectile dysfunction)

- Have CP/CPPS, IC, PBS, or Bladder Fasciculation Syndrome (BFS)

- Be willing to provide a saliva and urine sample

- Agree to complete several brief questionnaires

- Family member of someone with CP/CPPS, PBS, IC or BFS

- Live in the USA or Canada

Exclusion Criteria:

- Major structural/anatomical urinary tract abnormalities

- Underlying inborn or congenital conditions which affect the urinary tract

- Surgery/chemotherapy in the pelvic area

- Bacterial cause to CP/CPPS or recurrent UTI

- Traumatic cause to CP/CPPS
We found this trial at
Boston, Massachusetts 02115
Principal Investigator: Louis M Kunkel, PhD
Phone: 617-919-4552
Boston, MA
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