Alisporivir With pegIFN/RBV in Protease Inhibitor (PI) Treatment Failure Patients With Chronic Hepatitis C



Status:Terminated
Conditions:Hepatitis, Hepatitis, Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - 70
Updated:4/21/2016
Start Date:February 2012
End Date:February 2014

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A Multicenter, Single-arm Trial Evaluating the Safety and Efficacy of DEB025/Alisporivir in Combination With Pegylated Interferon-α2a and Ribavirin (Peg-IFNα2a/RBV) in Protease Inhibitor Treatment Failure Patients With Chronic Hepatitis C Genotype 1

The purpose of this study is to evaluate the overall efficacy, and safety profile, of triple
combination therapy of DEB025/pegIFN/RBV in chronic hepatitis C patients who failed prior
treatment with PI.


Inclusion criteria:

1. HCV GT1 patients with previous PI treatment failure.

2. Timing of the PI treatment. the minimum time from the last dose of previous PI
treatment to the first dose of study medication is three months.

3. Diagnosed Chronic hepatitis C virus infection

4. Infection with HCV genotype 1

Exclusion criteria:

1. Use of other investigational drugs at the time of enrollment,

2. History of hypersensitivity to any pegIFN or RBV.

3. Any null non-responders to prior pegIFN/RBV treatment,

Other protocol-defined inclusion/exclusion criteria may apply.
We found this trial at
23
sites
Arlington, Texas 76012
347
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Arlington, TX
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Alexandria, Virginia 22310
1122
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Alexandria, VA
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Bakersfield, California 93301
1184
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Bakersfield, CA
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Baltimore, Maryland 21287
1149
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Baltimore, MD
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Bradenton, Florida 32405
868
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Bradenton, FL
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Brockton, Massachusetts 02301
1445
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Brockton, MA
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Chicago, Illinois 60612
608
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Chicago, IL
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Cincinnati, Ohio 45229
727
mi
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Cincinnati, OH
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Dallas, Texas 75216
353
mi
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Dallas, TX
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Los Angeles, California 90095
1177
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Los Angeles, CA
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Miami, Florida 33136
1320
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Miami, FL
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Minneapolis, Minnesota 55402
551
mi
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Minneapolis, MN
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230 Park Avenue, 21st Floor
New York, New York 10169
1-888-669-6682)
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
1290
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New York, NY
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Newport News, Virginia 23606
1167
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Newport News, VA
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Palo Alto, California 94304
1330
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Palo Alto, CA
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Phoenix, Arizona 85012
851
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Phoenix, AZ
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Providence, Rhode Island 02908
1424
mi
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Providence, RI
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Sacramento, California 95825
1278
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Sacramento, CA
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San Diego, California 92123
1138
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San Diego, CA
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St. Louis, Missouri 63110
415
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St. Louis, MO
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Vancouver, British Columbia
1486
mi
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Vancouver,
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Ventura, California 93003
1216
mi
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Ventura, CA
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Wellington, Florida 33449
1281
mi
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Wellington, FL
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