In-Vivo Assessment of Silver Biomaterial Nano-Toxicity 32 Ppm

Inclusion Criteria:

- 18-80 years old without debilitating chronic disease or history of cardiovascular
event.

Exclusion Criteria:

- Women physically capable of becoming pregnant, who are not using 2 barrier methods of
birth control;

- Any female who is nursing;

- History of heavy metal allergy;

- History of asthma or Chronic Obstructive Pulmonary Disease;

- History of renal impairment;

- Symptoms of active upper respiratory disease at time of consent;

- Smoking more than 5 cigarettes or equivalent and not able to stop for 48 hours;

- Ability to discontinue chronic medications or nutraceuticals for 20 days or 5
half-lives of the agent, whichever is longer.