Switching From Insulin Glargine to Insulin Degludec in Subjects With Type 2 Diabetes Mellitus (BEGIN™)

Inclusion Criteria:

- Type 2 diabetes mellitus (diagnosed clinically) for at least 6 months

- HbA1c maximum 10 % by central laboratory analysis

- Current treatment with basal-oral therapy (BOT) (no prandial insulin ever) consisting
of: at least three months with insulin glargine once daily (average prescribed dose
must have been unchanged (within plus/minus 10%) for four weeks prior to Visit 1 as
confirmed by patient records or verbal confirmation by the subject) in combination
with stable (unchanged doses for at least 3 months prior to Visit 1) OAD (metformin,
insulin secretagogues, pioglitazone, sitagliptin or alpha-glucosidase-inhibitor)
treatment in any approved (according to label) dose or combination

Exclusion Criteria:

- Use within the last three months prior to Visit 1 of: Exenatide, Liraglutide or
Thiazoledinediones (TZDs) other than Pioglitazone

- Cardiovascular disease (CVD) defined as: stroke; decompensated heart failure New York
Heart Association (NYHA) class III or IV; myocardial infarction; unstable angina
pectoris; or coronary arterial bypass graft or angioplasty within the last six months
prior to Visit 1

- Recurrent severe hypoglycaemia (more than one severe hypoglycaemic episode during the
last 12 months), or hypoglycaemic unawareness as judged by the Investigator, or
hospitalisation for diabetic ketoacidosis during the previous six months

- Pregnancy, breast-feeding, the intention of becoming pregnant or not using adequate
contraceptive measures according to local requirements

- Previous participation in this trial. Participation is defined as started on trial
medication. Rescreening of screening failures is allowed only once within the limits
of the recruitment period

- Known or suspected hypersensitivity to trial products or related products