Genomic Structural Variation in Cancer Susceptibility
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Breast Cancer, Colorectal Cancer, Colorectal Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/11/2019 |
| Start Date: | October 2009 |
| End Date: | October 2019 |
This study will look for new types of gene changes that may be related to cancer in some
patients. Some gene changes (mutations) are passed on from parents to offspring (child).
Other gene changes are new and are seen for the first time in a child. They are not seen in
the parent.
Some of these gene changes may cause cancers in the offspring. We will look for gene changes
by studying patients with cancer their parents and family members without cancer. In this
study, we will be able to find gene changes that occur in the cancer patient but not in the
rest of the family. Knowing the role that new gene changes play in cancer risk may help us
find people at a higher risk of getting cancer.
patients. Some gene changes (mutations) are passed on from parents to offspring (child).
Other gene changes are new and are seen for the first time in a child. They are not seen in
the parent.
Some of these gene changes may cause cancers in the offspring. We will look for gene changes
by studying patients with cancer their parents and family members without cancer. In this
study, we will be able to find gene changes that occur in the cancer patient but not in the
rest of the family. Knowing the role that new gene changes play in cancer risk may help us
find people at a higher risk of getting cancer.
Inclusion Criteria:
- Proband must have living unaffected biologic mother and father available and eligible
for participation in the study with one of the following (both incident and prevalent
cases will be collected):
- Colorectal cancer diagnosed at or under the age of 50.
- Breast cancer diagnosed at or under the age of 45.
- Germ cell tumor diagnosed at or under the age of 40.
- Pediatric cancer of any type diagnosed at or under the age of 21
- Adult cancer or pre-neoplastic condition of any type diagnosed at or under the
age of 40
- Cancer at any age in 2 or more siblings suggestive of a genetic etiology, such as
brothers with testicular germ cell tumor or sisters with breast cancer and
ovarian cancer
- Parents:
- Must be the biologic mother and biologic father of affected proband.
- Must have (by self-report) no history of cancer other than non-melanomatous skin
cancer or cervical cancer in situ except in the case of inclusion criteria #6..
- In certain clinical situations, parent(s) with cancer may be included at the
discretion of the Principal Investigator, if the Principal Investigator deems
that the etiology of cancer in the parent(s) and proband are biologically
unrelated.
- Sibling(s):
- Must be age 18 or older and have same biologic parents as proband.
Exclusion Criteria:
- Known genetic mutation in proband or a family history that is indicative of hereditary
cancer susceptibility.
We found this trial at
1
site
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
Click here to add this to my saved trials
