A Study of Taspoglutide Versus Pioglitazone in Patients With Type 2 Diabetes



Status:Completed
Conditions:Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 75
Updated:8/3/2016
Start Date:May 2009
End Date:November 2010

Use our guide to learn which trials are right for you!

A Multicenter, Randomized, Double Blind (Double Dummy), Active Controlled Study to Compare the Safety, Tolerability and Effect on Glycemic Control of Taspoglutide Versus Pioglitazone in Type 2 Diabetes Patients Inadequately Controlled on Therapy With Sulfonylurea or Metformin Plus Sulfonylurea

This double-blind, double-dummy 3 arm study will evaluate the efficacy, safety and
tolerability of taspoglutide versus pioglitazone in patients with type 2 diabetes mellitus
inadequately controlled with sulfonylurea monotherapy or sulfonylurea plus metformin
combination therapy. After an initial screening period, patients will be randomized to one
of 3 groups, to receive a)taspoglutide 10mg sc weekly, b)taspoglutide 20mg sc weekly after 4
weeks of taspoglutide 10mg sc weekly or c)pioglitazone 45mg/day po after 4 weeks of
pioglitazone 30mg/day po.The anticipated time on study treatment is 24 months, and the
target sample size is 500+ individuals.


Inclusion Criteria:

- adult patients, 18-75 years of age;

- type 2 diabetes mellitus;

- treated with stable sulfonylurea monotherapy or metformin + sulfonylurea for >=12
weeks prior to screening;

- HbA1c >=7.0% and <=10% at screening;

- stable weight +/-5% for >=12 weeks prior to screening.

Exclusion Criteria:

- type 1 diabetes, diabetes resulting from pancreatic injury, or secondary forms of
diabetes;

- clinically significant diabetic complications;

- clinically symptomatic gastrointestinal disease;

- >3 episodes of severe hypoglycemia within 6 months before screening.
We found this trial at
56
sites
Mooresville, North Carolina 28117
2099
mi
from 91732
Mooresville, NC
Click here to add this to my saved trials
1919
mi
from 91732
Atlanta, GA
Click here to add this to my saved trials
2550
mi
from 91732
Ayer, MA
Click here to add this to my saved trials
2103
mi
from 91732
Beaver, PA
Click here to add this to my saved trials
712
mi
from 91732
Bend, OR
Click here to add this to my saved trials
2388
mi
from 91732
Berlin, NJ
Click here to add this to my saved trials
2277
mi
from 91732
Bethesda, MD
Click here to add this to my saved trials
1710
mi
from 91732
Biloxi, MS
Click here to add this to my saved trials
2430
mi
from 91732
Brick, NJ
Click here to add this to my saved trials
16
mi
from 91732
Buena Park, CA
Click here to add this to my saved trials
7516
mi
from 91732
Camperdown,
Click here to add this to my saved trials
1729
mi
from 91732
Chicago, IL
Click here to add this to my saved trials
2078
mi
from 91732
Chiefland, FL
Click here to add this to my saved trials
19
mi
from 91732
Chino, CA
Click here to add this to my saved trials
1902
mi
from 91732
Columbus, GA
Click here to add this to my saved trials
1940
mi
from 91732
Conyers, GA
Click here to add this to my saved trials
2318
mi
from 91732
Coral Gables, FL
Click here to add this to my saved trials
1225
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
2187
mi
from 91732
Daytona Beach, FL
Click here to add this to my saved trials
2202
mi
from 91732
Durham, NC
Click here to add this to my saved trials
1715
mi
from 91732
Evansville, IN
Click here to add this to my saved trials
1400
mi
from 91732
Fargo, ND
Click here to add this to my saved trials
1963
mi
from 91732
Ferndale, MI
Click here to add this to my saved trials
1174
mi
from 91732
Grand Island, NE
Click here to add this to my saved trials
1357
mi
from 91732
Houston, TX
Click here to add this to my saved trials
1609
mi
from 91732
Jackson, MS
Click here to add this to my saved trials
1994
mi
from 91732
Kingsport, TN
Click here to add this to my saved trials
13
mi
from 91732
Los Angeles, CA
Click here to add this to my saved trials
1718
mi
from 91732
Madisonville, KY
Click here to add this to my saved trials
627
mi
from 91732
Medford, OR
Click here to add this to my saved trials
1648
mi
from 91732
Metairie, LA
Click here to add this to my saved trials
1511
mi
from 91732
Minneapolis, MN
Click here to add this to my saved trials
2435
mi
from 91732
New York, NY
Click here to add this to my saved trials
Olive Branch, Mississippi 38654
1599
mi
from 91732
Olive Branch, MS
Click here to add this to my saved trials
1904
mi
from 91732
Panama City, FL
Click here to add this to my saved trials
2375
mi
from 91732
Philadelphia, PA
Click here to add this to my saved trials
2180
mi
from 91732
Port Charlotte, FL
Click here to add this to my saved trials
Rancho Cucamonga, California 91730
25
mi
from 91732
Rancho Cucamonga, CA
Click here to add this to my saved trials
2267
mi
from 91732
Richmond, VA
Click here to add this to my saved trials
368
mi
from 91732
Roseville, CA
Click here to add this to my saved trials
1919
mi
from 91732
Roswell, GA
Click here to add this to my saved trials
570
mi
from 91732
Salt Lake City, UT
Click here to add this to my saved trials
24
mi
from 91732
Santa Ana, CA
Click here to add this to my saved trials
2344
mi
from 91732
Scranton, PA
Click here to add this to my saved trials
South Burlington, Vermont 05403
2469
mi
from 91732
South Burlington, VT
Click here to add this to my saved trials
939
mi
from 91732
Spokane, WA
Click here to add this to my saved trials
1606
mi
from 91732
Springfield, IL
Click here to add this to my saved trials
2124
mi
from 91732
St Petersburg, FL
Click here to add this to my saved trials
2428
mi
from 91732
Staten Island, NY
Click here to add this to my saved trials
2426
mi
from 91732
Toms River, NJ
Click here to add this to my saved trials
2395
mi
from 91732
Trenton, NJ
Click here to add this to my saved trials
835
mi
from 91732
Vancouver, WA
Click here to add this to my saved trials
2569
mi
from 91732
Waltham, MA
Click here to add this to my saved trials
1712
mi
from 91732
Waukesha, WI
Click here to add this to my saved trials
2126
mi
from 91732
Winston-Salem, NC
Click here to add this to my saved trials
2184
mi
from 91732
Winter Park, FL
Click here to add this to my saved trials