Evaluation of Serial Troponin and Cardiac Multimarkers at the Point of Care in the Emergency Department



Status:Withdrawn
Conditions:Angina, Cardiology, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:February 2010
End Date:May 2010

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This is a multi-center study to assess the diagnostic accuracy of the Troponin I assay in
the Biosite Triage Cardio3 Panel at the point-of-care (POC) in adults presenting to the
emergency department with possible acute myocardial infarction (AMI).


Inclusion Criteria:

- 18 years of age or older at time of enrollment

- Presenting to the ED within 6 hours from onset of chest discomfort (pain, pressure,
tightness, etc) consistent with a possible diagnosis of AMI or ACS and with an
initial ECG non-diagnostic for injury (or injury equivalent resulting in emergent
reperfusion therapy). (NOTE: Subjects who have chest discomfort that is episodic or
stuttering in nature may be included if the ED presentation is within 6 hours of
symptom onset.)

- Experiencing at least 30 minutes of chest pain or other anginal equivalent symptoms.
(Note: Subjects who have symptoms of shorter duration due to pharmacologic
intervention may be included.)

Exclusion Criteria:

- Patient (or Legal Representative) unable or unwilling to provide written informed
consent.

- Patient unwilling or unlikely to comply with study procedures, including
protocol-specified blood sampling or telephone follow-up at 30 days and 6 months.

- Vulnerable populations as deemed inappropriate for study by site principal
investigator.

- ST-elevation or other ECG criteria that result that is diagnostic for AMI and results
in patient being sent for percutaneous coronary interventions (PCI) or being treated
with thrombolytics6.

- Pulmonary Edema requiring CPAP, BIPAP, or mechanical ventilation

- Tachyarrhythmias (SVT, V-Tach, rapid atrial fib)

- End Stage Renal Disease on Hemodialysis

- Cardiac Arrest prior to arrival

- Implantable Defibrillator firing prior to arrival

- Hemodynamically unstable patients

- Trauma injury to the chest
We found this trial at
6
sites
Johnson City, Tennessee 37604
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Chattanooga, Tennessee 37403
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Chattanooga, TN
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2160 South 1st Avenue
Maywood, Illinois 60153
(888) 584-7888
Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...
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Maywood, IL
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320 E North Ave
Pittsburgh, Pennsylvania 15212
(412) 359-3131
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
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Pittsburgh, PA
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Portland, Oregon 97227
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Portland, OR
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101 Nicolls Rd
Stony Brook, New York 11794
(631) 444-4000
Stony Brook University Medical Center Stony Brook Medicine expresses our shared mission of research, clinical...
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Stony Brook, NY
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