Autologous Neo-Bladder Construct in Non-Neurogenic Overactive Bladder and Urge Predominant Incontinence
| Status: | Withdrawn |
|---|---|
| Conditions: | Overactive Bladder |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/10/2018 |
| Start Date: | January 2008 |
| End Date: | January 2008 |
An Open Label Multi-center Study of Augmentation Cystoplasty Using an Autologous Neo-Bladder Construct in Subjects With Non-Neurogenic Overactive Bladder and Urge Predominant Incontinence
Subjects with non-neurogenic over-active bladder will be enrolled. The hypothesis is that
augmentation cystoplasty using an autologous neo-bladder construct will increase functional
capacity and thereby reduce the number of micturition episodes per day in subjects with
non-neurogenic over active bladder and urge predominant incontinence.
augmentation cystoplasty using an autologous neo-bladder construct will increase functional
capacity and thereby reduce the number of micturition episodes per day in subjects with
non-neurogenic over active bladder and urge predominant incontinence.
Subjects with non-neurogenic over-active bladder and urge predominant incontinence who are
intolerant to medical therapy or have persistence of symptoms despite medical therapy and
require augmentation cystoplasty will be enrolled. The hypothesis is that augmentation
cystoplasty using an autologous neo-bladder construct will increase functional capacity and
thereby reduce the number of micturition episodes per day in subjects with non-neurogenic
over active bladder and urge predominant incontinence.
intolerant to medical therapy or have persistence of symptoms despite medical therapy and
require augmentation cystoplasty will be enrolled. The hypothesis is that augmentation
cystoplasty using an autologous neo-bladder construct will increase functional capacity and
thereby reduce the number of micturition episodes per day in subjects with non-neurogenic
over active bladder and urge predominant incontinence.
Inclusion Criteria:
- History of non-neurogenic overactive bladder for at least 12 months prior to study
entry
- Intolerance to medical therapy or persistence of symptoms despite medical therapy
Exclusion Criteria:
- Subjects with stress incontinence or mixed incontinence where the predominant
component is stress incontinence
- Use of Botulinum Toxin A injections into the bladder within the previous 6 months
- Presence of a neuromodulator
- Using catheterization as a way to control incontinence
- History of bladder cancer
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