Prometa Pharmacotherapy for Methamphetamine Dependence

Using a double-blind placebo design, the effectiveness of the Prometa protocol for
methamphetamine dependence will be investigated as compared to a placebo condition. The
procedure utilizes a combination of medications delivered both orally and by infusion in a
controlled medical setting. Participants will be randomly assigned to the active medication
or placebo condition, and will receive medications for 40 days, including two inpatient
hospitalization phases of three days each. All participants will also receive once-weekly
psychosocial cognitive-behavioral therapy throughout the 106 day study duration. A variety
of data will be collected throughout the study, including psychological, cognitive, medical,
and laboratory assessments.

Inclusion Criteria:

- Be at least 18 years-of-age;

- Have a DSM-IV-TR diagnosis of methamphetamine abuse or dependence as determined by
SCID;

- Be seeking treatment for methamphetamine abuse or dependence;

- Be able to understand, and having understood, provide written informed consent;

- If female and of child bearing potential, agree to use an approved method of birth
control or be surgically sterile;

- Have completed all other psychological assessments; -Have used methamphetamine at
least 4 of the last 30 days. -

Exclusion Criteria:

- Have current dependence, defined by DSM-IV-TR criteria, on any psychoactive substance
other than methamphetamine, alcohol, nicotine, or marijuana or physiological
dependence on alcohol requiring medical detoxification (CIWA-AR score ≥ 15);

- Be mandated by the court to obtain treatment for methamphetamine-abuse or dependence;

- Be anyone who, in the opinion of the investigator, would not be expected to complete
the study protocol due to probable incarceration or relocation from the clinic area;

- Have a current or previous psychiatric, or a neurological disorder including but not
limited to epilepsy and absence seizures, fainting spells, brain disease, dementia,
or any disorder that, in the opinion of the study physician requires ongoing
treatment that would make study participation unsafe or which would make treatment
compliance difficult.

- Have a psychiatric disorder, as assessed by the SCID, or a neurological disorder
including but not limited to epilepsy and absence seizures, brain disease, dementia
or any disorder that, in the opinion of the study physician, requires ongoing
treatment that would make study participation unsafe or which would make treatment
compliance difficult;

- Have had electroconvulsive therapy within the past 3 months preceding screening; Have
current suicidal ideation or plan (within the past 30 days) as assessed by the SCID;

- Be pregnant or lactating;

- Have serious medical illnesses (including, but not limited to: uncontrolled
hypertension, significant heart disease including myocardial infarction within one
year of enrollment, or any clinically significant cardiovascular abnormality (ECG),
hepatic, renal or gastrointestinal disorders that could result in a clinically
significant alteration of metabolism or excretion of the study agent, potentially
life-threatening or progressive medical illness other than addiction that may
compromise subject safety or study conduct);

- Have clinically significant abnormal laboratory values;

- Benzodiazepine and/or similar sedative-hypnotic or anxiolytic use or abuse within 15
days of potential PROMETA Treatment;

- Must not be habituated to benzodiazepines and must provide a urine sample that is
negative for benzodiazepines;

- Must not be taking supra-therapeutic doses of zolpidem (Ambien TM) or zaleplon
(Sonata TM); Taking clonazepam (Klonopin TM) or other benzodiazepine;

- Patients must not be taking cyclic antidepressants, lithium, methylxanthines,
isoniazid, propoxyphene, monoamine oxidase inhibitors, buproprion HCL, and
cyclosporine.

- Have AIDS;

- Have active tuberculosis (positive tuberculin test and confirmatory diagnostic chest
x-ray);

- Have known or suspected hypersensitivity to PROMETA;

- Have been treated with PROMETA for any reason currently or during the past year;

- Have any disorder or condition that, in the opinion of the study physician, would
make study participation difficult or unsafe.