Childhood Origins of Asthma (COAST)
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Allergy, Allergy, Asthma |
| Therapuetic Areas: | Otolaryngology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/2/2019 |
| Start Date: | October 1998 |
| End Date: | June 2021 |
Rhinovirus Infection and Asthma in Childhood and Adolescents
Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or
events repetitively emerge for their ability to significantly influence asthma inception in
the first decade of life: immune response aberrations, which appear to be defined best by the
concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV);
and some form of gene by environment interaction that needs to occur at a critical time
period in the development of the immune system or the lung. It remains to be firmly
established, however, how any one or all of these factors, either independently or
interactively, influence the development of childhood asthma. Thus, our efforts to determine
and define the importance of these three factors to asthma pathogenesis are the focus and
goal of this current grant application.
events repetitively emerge for their ability to significantly influence asthma inception in
the first decade of life: immune response aberrations, which appear to be defined best by the
concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV);
and some form of gene by environment interaction that needs to occur at a critical time
period in the development of the immune system or the lung. It remains to be firmly
established, however, how any one or all of these factors, either independently or
interactively, influence the development of childhood asthma. Thus, our efforts to determine
and define the importance of these three factors to asthma pathogenesis are the focus and
goal of this current grant application.
No more description necessary.
Inclusion Criteria:
- children who had one or more parent with a history of allergy or asthma
Exclusion Criteria:
- pre term infants
- low birth weight infants
- respiratory distress at birth
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