Quetiapine Fumarate (Seroquel) for the Treatment of Alcohol Dependence.

The purpose of this study is to obtain preliminary data regarding the safety, efficacy and
tolerability of quetiapine [Seroquel (SQL)] in treating Type A vs B alcohol dependent
outpatients seeking treatment.

Inclusion Criteria:

1. Male or female and 18-65 years old.

2. Has a DSM-IV diagnosis of current alcohol dependence.

3. Has either Type A or Type B alcohol dependence, determined by cut-off scores for
drinking amounts per day (TLFB), depression symptoms (Hamilton Depression Rating
Scale--HDRS; Hamilton, 1967), and number of childhood antisocial personality
symptoms. These three variables were selected based on recently published data on
alcohol subtyping by Pettinati et al., 2000b).

4. Meets the following drinking criteria, measured by TLFB: a. drink within 30 days of
starting pharmacotherapy treatment, b. reports a minimum of 48 standard alcoholic
drinks (avg 12 drinks/wk) in a consecutive 30-day period over the 90-day period prior
to starting pharmacotherapy (i.e., a minimum of 40% days drinking), and c. has 2 or
more days of heavy drinking (defined as 5 or more drinks per day in males and 4 or
more drinks per day in females) in this same pre-treatment period. [Note: To be a
subject in the study, the patient must have been drinking enough in the 90 days
before the trial so that a baseline exists in order to then measure reductions in
drinking during the trial.]

5. Prior to starting pharmacotherapy, scores below 8 on the Clinical Institutes
Withdrawal Assessment for Alcohol (CIWA; Shaw et al, 1981), and has at least 3
consecutive days of abstinence, as determined by subject report, breathalyzer
measures, and a collateral report.

6. Speaks, understands and prints in English.

7. Gives written informed consent.

Exclusion Criteria:

1. Has evidence of dependence on a substance other than alcohol (except nicotine), test
positive on the urine drug screen (with the exception of THC) in the screening week
(only one repeat testing permitted), or require inpatient detoxification for any
substance.

2. Has hepatocellular disease indicated by elevations of SGPT (ALT) and SGOT (AST) of at
least 4.5 times normal after the required 3 days of abstinence, or elevated bilirubin
(>1.3).

3. Patients with hepatocellular disease as evidenced by AST or ALT levels at least 2
times normal who test positive on a screening test for hepatitis A, B or C.

4. Meets diagnostic criteria for a current unstable or serious psychiatric or medical
illness. For example, bipolar affective disorder, schizophrenia or any other
psychotic disorder, or organic mental disorder; has serious heart, lung, kidney,
immune system, GI tract (ulcerative colitis, regional enteritis, or gastrointestinal
bleeding) disease.

5. Has taken any psychotropic medications (or disulfiram) regularly within the last 2
weeks or needs immediate treatment with a psychotropic medication (with the exception
of detoxification medications or benadryl used sparingly for sleep);

6. Tests positive on a pregnancy test, is contemplating pregnancy in the next 12 months,
is nursing, or is not using an effective contraceptive method if the S is of
child-bearing potential.

7. Has known hypersensitivity to antipsychotics.

8. Has participated in any investigational drug trial within 30 days prior to the study.

9. History of seizures including alcohol withdrawal seizures.

10. History of head trauma.

11. Family history of seizures.