Novel Epothilone Plus Capecitabine Versus Capecitabine Alone in Patients With Advanced Breast Cancer



Status:Completed
Conditions:Breast Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:September 2003
End Date:March 2008

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A Phase III Trial of Novel Epothilone BMS-247550 Plus Capecitabine Versus Capecitabine Alone in Patients With Advanced Breast Cancer Previously Treated With or Resistant to an Anthracycline and Who Are Taxane Resistant

The purpose of this clinical research study is to learn if BMS-247550 added to the approved
therapy of capecitabine is better than capecitabine alone in shrinking or slowing the growth
of the cancer in women with metastatic breast cancer who are resistant to taxane and
received anthracycline chemotherapy. The safety of this treatment will also be studied.


- Patients must have received either 2 or 3 prior chemotherapy regimens including
adjuvant or neoadjuvant therapy.

- Prior treatment must have included both an anthracycline (i.e., doxorubicin or
epirubicin) and a taxane (i.e., paclitaxel or docetaxel).

- Patients must have received a minimum cumulative dose of anthracycline or must be
resistant to an anthracycline.

- Patients must be resistant to taxane therapy.

- Patients may not have any history of brain and/or leptomeningeal metastases.

- Patients may not have CTC Grade 2 or greater neuropathy (motor or sensory).

- Patients may have not have had prior treatment with an epothilone and/or capecitabine
(i.e., Xeloda)
We found this trial at
33
sites
Austin, Texas 78701
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Albuquerque, New Mexico 87108
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Albuquerque, NM
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Baltimore, Maryland 21237
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Baltimore, MD
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Burlington, Massachusetts
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Burlington, MA
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Burlington, Vermont
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Burlington, VT
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Capital Federal, Buenos Aires
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Capital Federal,
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Columbia, Missouri 65212
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Columbia, MO
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Columbia, South Carolina 29201
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Columbia, SC
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Columbus, Ohio 43219
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Columbus, OH
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Denver, Colorado 80220
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Denver, CO
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Greenville, South Carolina 29615
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Greenville, SC
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Hartford, Connecticut 06106
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Hartford, CT
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Houston, Texas 77030
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Houston, TX
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Jackson, Mississippi 39216
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Jackson, MS
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Kansas City, Missouri 64108
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Kansas City, MO
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Knoxville, Tennessee 37920
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Knoxville, TN
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Little Rock, Arkansas 72201
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Little Rock, AR
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Livingston, New Jersey 07039
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Livingston, NJ
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Morgantown, West Virginia 26505
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Morgantown, WV
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Nashville, Tennessee 37203
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Nashville, TN
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New Brunswick, New Jersey 08901
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New Brunswick, NJ
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New York, New York 10016
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New York, NY
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Ogden, Utah
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Ogden, UT
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Oklahoma City, Oklahoma 73103
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Oklahoma City, OK
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Omaha, Nebraska 68114
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Omaha, NE
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Orlando, Florida 32803
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Orlando, FL
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Pittsburgh, Pennsylvania 15240
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Pittsburgh, PA
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Saint Louis, Missouri 63104
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Saint Louis, MO
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San Francisco, California 94107
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San Francisco, CA
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Tacoma, Washington
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Tacoma, WA
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Tulsa, Oklahoma 74136
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Tulsa, OK
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Vallejo, California 94589
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Vallejo, CA
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Washington, District of Columbia 20010
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Washington,
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