Investigating Severe Acute Respiratory Syndrome (SARS)
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2003 |
| End Date: | May 2007 |
An Investigation of the Inflammatory Response in Severe Acute Respiratory Syndrome (SARS)
Severe Acute Respiratory Syndrome (SARS) is a newly recognized illness that can be fatal.
The purpose of this study is to better understand SARS by collecting samples of blood and
other body fluids of people who have been exposed to SARS or who are suspected to have the
illness.
Up to 300 volunteers aged 18 years or older will be enrolled in this study. Participants
will donate blood samples and, if appropriate, samples of fluid from the lungs, nose, or
throat. Researchers will test these samples for proteins that control or mediate
inflammatory or immune responses. The patterns of these proteins will reveal how SARS
affects the body and the efforts the body makes to fight off the infection.
The purpose of this study is to better understand SARS by collecting samples of blood and
other body fluids of people who have been exposed to SARS or who are suspected to have the
illness.
Up to 300 volunteers aged 18 years or older will be enrolled in this study. Participants
will donate blood samples and, if appropriate, samples of fluid from the lungs, nose, or
throat. Researchers will test these samples for proteins that control or mediate
inflammatory or immune responses. The patterns of these proteins will reveal how SARS
affects the body and the efforts the body makes to fight off the infection.
Severe acute respiratory syndrome (SARS) is a newly recognized illness associated with
substantial mobidity and mortality. Patients develop fever followed by rapidly progressive
and even fatal respiratory disease. SARS is associated with infection with a novel
coronavirus. The evaluation of the inflammatory responses evoked by SARS may yield
information regarding its pathogenesis and help with patient management. This protocol,
then, merely aims to study disease pathogenesis and natural history, by studying samples and
data that are collected by outside physicians or physicians at the Clinical Center and sent
for evaluation of the inflammatory response.
substantial mobidity and mortality. Patients develop fever followed by rapidly progressive
and even fatal respiratory disease. SARS is associated with infection with a novel
coronavirus. The evaluation of the inflammatory responses evoked by SARS may yield
information regarding its pathogenesis and help with patient management. This protocol,
then, merely aims to study disease pathogenesis and natural history, by studying samples and
data that are collected by outside physicians or physicians at the Clinical Center and sent
for evaluation of the inflammatory response.
- INCLUSION CRITERIA - CASES:
Patients fulfilling the CDC case definition or WHO definition for suspected or probable
SARS.
Newly identified patients found to have recovered from SARS can also be enrolled.
EXCLUSION CRITERIA - CASES:
Patients diagnosed with alternative illnesses as the cause of the symptoms.
INCLUSION CRITERIA - HEALTHY VOLUNTEERS:
For the purpose of this study, a healthy volunteer is defined as a healthy male or female,
age 18 and above.
Volunteers will be excluded if they have a pre-existing or concurrent serious chronic
medical or psychiatric illness.
Chronic medication use will be evaluated on a case-by-case basis.
They will also be excluded if they have received an investigational drug in the past 3
months.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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