Genetic Study in Patients With Stage II or Stage III Colon Cancer



Status:Completed
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 69
Updated:7/14/2016
Start Date:February 1999
End Date:August 2006

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The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer

RATIONALE: Genetic studies may help in understanding the genetic processes that cause some
types of cancer.

PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III
colon cancer.

OBJECTIVES:

- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.

- Determine if patient prognosis is dependent on the region of 8p AI.

- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
on 8p.

- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.

OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
studies.

DISEASE CHARACTERISTICS:

- Diagnosis of resectable stage II or III adenocarcinoma of the colon

- Participated in NCCTG-914653

- DNA extracted from both normal and tumor tissue

PATIENT CHARACTERISTICS:

Age

- Under 70
We found this trial at
2
sites
1189
mi
from 91732
Calgary,
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Duluth, Minnesota 55805
1610
mi
from 91732
Duluth, MN
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