Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes

Healthy collegiate athletes (football, soccer, rugby, hockey, and volleyball) will take
Nicotinamide Riboside (NR) or placebo twice daily for 84 days. Pre- and post-intervention
evaluations include physical assessment, blood tests for safety and toxicity monitoring,
blood tests for biomarkers, neurologic testing, quality of life questionnaires, and the 31P
MRI exam.

Inclusion Criteria:

- Adult current and former (within 2 years) collegiate athletes (football, rugby,
soccer, hockey, and volleyball)

- Body mass index (estimated based on height and weight) from 23 to 37

- Willing to provide informed consent, ingest test substance, and provide blood
specimens

- Willing to comply with study instructions and maintain current level of physical
activity throughout the study

Exclusion Criteria:

- History of loss of consciousness of more than 5 minutes

- Contraindications to Magnetic Resonance Imaging (MRI), such as implanted medical
devices, metal objects, or pacemakers

- History of epilepsy

- History of more than 3 concussions

- History of headache preceding a concussion

- History of depression preceding a concussion

- History of developmental delays or Attention Deficit Hyperactivity Disorder (ADHD)

- History of post-traumatic seizures

- History of complex spine and/or skull trauma