Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes



Status:Recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - Any
Updated:2/2/2019
Start Date:September 2016
End Date:June 2020
Contact:Stephanie Lindeen, RN
Email:athletesstudy@mayo.edu
Phone:507-284-4799

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Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes and a Comparison of the Effect of Nicotinamide Riboside Supplementation on Brain NAD+ Levels

Can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of NAD+ in the brain as
measured by 31P MRS?

Healthy collegiate athletes (football, soccer, rugby, hockey, and volleyball) will take
Nicotinamide Riboside (NR) or placebo twice daily for 84 days. Pre- and post-intervention
evaluations include physical assessment, blood tests for safety and toxicity monitoring,
blood tests for biomarkers, neurologic testing, quality of life questionnaires, and the 31P
MRI exam.

Inclusion Criteria:

- Adult current and former (within 2 years) collegiate athletes (football, rugby,
soccer, hockey, and volleyball)

- Body mass index (estimated based on height and weight) from 23 to 37

- Willing to provide informed consent, ingest test substance, and provide blood
specimens

- Willing to comply with study instructions and maintain current level of physical
activity throughout the study

Exclusion Criteria:

- History of loss of consciousness of more than 5 minutes

- Contraindications to Magnetic Resonance Imaging (MRI), such as implanted medical
devices, metal objects, or pacemakers

- History of epilepsy

- History of more than 3 concussions

- History of headache preceding a concussion

- History of depression preceding a concussion

- History of developmental delays or Attention Deficit Hyperactivity Disorder (ADHD)

- History of post-traumatic seizures

- History of complex spine and/or skull trauma
We found this trial at
2
sites
Minneapolis, Minnesota 55455
Principal Investigator: Xiao-Hong Zhu, Ph.D.
Phone: 612-624-9926
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Minneapolis, MN
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Rochester, Minnesota 55905
Principal Investigator: Brent A Bauer, MD
Phone: 507-293-2740
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Rochester, MN
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