Efficacy Study of Fedovapagon for Nocturia in Men With Benign Prostatic Hyperplasia (BPH)



Status:Completed
Conditions:Hematology, Urology
Therapuetic Areas:Hematology, Nephrology / Urology
Healthy:No
Age Range:18 - Any
Updated:11/2/2018
Start Date:March 2016
End Date:August 2017

Use our guide to learn which trials are right for you!

A Randomised, Double-blind, Placebo-controlled, Multi-centre Study to Investigate the Efficacy and Safety of Fedovapagon in the Treatment of Nocturia in Men With Benign Prostatic Hyperplasia (BPH) (EQUINOC Study)

This study will investigate the efficacy and safety of fedovapagon in the treatment of
nocturia in men with BPH.

Fedovapagon is a selective vasopressin V2 receptor (V2R) agonist that has an antidiuretic
effect through stimulation of V2 receptors in the kidney and is being developed for the
treatment of nocturia. Nocturia, defined as the complaint that the individual has to wake at
night one or more times to void, is a common condition and shows an age-dependent increase in
both prevalence and severity (number of nocturnal voids). It has a significant detrimental
impact on the quality of life in patients with benign prostatic hyperplasia (BPH).

The purpose of this study is to determine the efficacy and safety of fedovapagon in the
treatment of nocturia with BPH.

Inclusion Criteria:

- Adult males ≥18 years [no upper limit]

- Benign prostatic hyperplasia

- Persistent nocturia despite previous lifestyle modification advice including
appropriate fluid management

- Serum sodium not below lower limit of normal prior to randomization

- Provide signed and dated informed consent before any study-specific procedures are
conducted.

- Able to comply with the requirements of the study.

Exclusion Criteria:
We found this trial at
50
sites
Albuquerque, New Mexico
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
?
mi
from
Akron, OH
Click here to add this to my saved trials
Anniston, Alabama
?
mi
from
Anniston, AL
Click here to add this to my saved trials
Aventura, Florida
?
mi
from
Aventura, FL
Click here to add this to my saved trials
?
mi
from
Avon, IN
Click here to add this to my saved trials
Bradenton, Florida
?
mi
from
Bradenton, FL
Click here to add this to my saved trials
Bristol, Tennessee
?
mi
from
Bristol, TN
Click here to add this to my saved trials
Cary, North Carolina
?
mi
from
Cary, NC
Click here to add this to my saved trials
Charleston, South Carolina
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Clearwater, Florida
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Clearwater, Florida
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Clinton, Utah 84015
?
mi
from
Clinton, UT
Click here to add this to my saved trials
Concord, North Carolina
?
mi
from
Concord, NC
Click here to add this to my saved trials
Coral Gables, Florida
?
mi
from
Coral Gables, FL
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Deland, Florida
?
mi
from
Deland, FL
Click here to add this to my saved trials
Englewood, New Jersey 07631
?
mi
from
Englewood, NJ
Click here to add this to my saved trials
Garden City, New York
?
mi
from
Garden City, NY
Click here to add this to my saved trials
Goodyear, Arizona
?
mi
from
Goodyear, AZ
Click here to add this to my saved trials
Greenbelt, Maryland
?
mi
from
Greenbelt, MD
Click here to add this to my saved trials
Greer, South Carolina
?
mi
from
Greer, SC
Click here to add this to my saved trials
Hialeah, Florida
?
mi
from
Hialeah, FL
Click here to add this to my saved trials
High Point, North Carolina
?
mi
from
High Point, NC
Click here to add this to my saved trials
?
mi
from
Houston, TX
Click here to add this to my saved trials
Lawrenceville, New Jersey
?
mi
from
Lawrenceville, NJ
Click here to add this to my saved trials
Lincoln, California
?
mi
from
Lincoln, CA
Click here to add this to my saved trials
?
mi
from
Miami, FL
Click here to add this to my saved trials
Missoula, Montana
?
mi
from
Missoula, MT
Click here to add this to my saved trials
Mount Pleasant, South Carolina
?
mi
from
Mount Pleasant, SC
Click here to add this to my saved trials
Murrieta, California
?
mi
from
Murrieta, CA
Click here to add this to my saved trials
New York, New York
?
mi
from
New York, NY
Click here to add this to my saved trials
Newburgh, New York 12550
?
mi
from
Newburgh, NY
Click here to add this to my saved trials
?
mi
from
Ocala, FL
Click here to add this to my saved trials
?
mi
from
Ogden, UT
Click here to add this to my saved trials
Omaha, Nebraska
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Pembroke Pines, Florida
?
mi
from
Pembroke Pines, FL
Click here to add this to my saved trials
Poughkeepsie, New York
?
mi
from
Poughkeepsie, NY
Click here to add this to my saved trials
Raleigh, North Carolina
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
Richmond, Virginia
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Saint Petersburg, Florida
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
Salt Lake City, Utah
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
San Antonio, Texas
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Diego, California
?
mi
from
San Diego, CA
Click here to add this to my saved trials
San Diego, California
?
mi
from
San Diego, CA
Click here to add this to my saved trials
?
mi
from
Tampa, FL
Click here to add this to my saved trials
?
mi
from
Topeka, KS
Click here to add this to my saved trials
Warwick, Rhode Island
?
mi
from
Warwick, RI
Click here to add this to my saved trials
Wichita, Kansas
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Wilmington, North Carolina
?
mi
from
Wilmington, NC
Click here to add this to my saved trials
Winston-Salem, North Carolina
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials