Neurocircuitry of Obsessive-Compulsive Disorder: Modulation by Transcranial Magnetic Stimulation



Status:Recruiting
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 70
Updated:3/6/2019
Start Date:June 2015
End Date:May 2020
Contact:Benjamin Greenberg, MD, PhD
Email:benjamin_greenberg@brown.edu
Phone:(401) 455-6602

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Neurocircuitry of OCD: Effects Of Modulation

The purpose of this study is to test the effects of non-invasive neuromodulation,
transcranial magnetic stimulation on brain function in individuals with obsessive-compulsive
disorder (OCD). This study is focused on the mechanism(s) by which brain stimulation might
change the functioning of regions implicated in OCD, and thereby inform possible future
therapeutic uses.


Inclusion Criteria:

- Current primary OCD diagnosis and current Y-BOCS total score of ≥16

- 18-70 years of age

- Ability to speak, read, write, and understand English sufficiently well to complete
study procedures and provide informed consent

- No use of psychiatric medications or stable psychiatric medication use for a minimum
of 6 week prior to study entry

- Ongoing psychotherapy allowed if already established for three months or more before
study entry

Exclusion Criteria:

- History of primary psychotic disorder or bipolar disorder

- Present acute suicidality

- History of head injury, epilepsy, or other clinically significant neurological illness
except tic disorders

- Active systemic medical (metabolic, endocrine, chronic inflammatory, vascular,
autoimmune) disease

- Premorbid intelligence quotient (IQ) estimate < 80

- Visual disturbance (<20/40 Snellen visual acuity, corrected)

- Current, or alcohol or illicit substance abuse/dependence in the last 3 months

- Contraindications to TMS or MRI: metallic foreign objects, e.g., aneurysm
clips/pacemakers, or questionable history of metal fragments, claustrophobia

- Women who are pregnant or breastfeeding. All women participants of reproductive age
are required to have a negative pregnancy test prior to enrollment and use medically
acceptable birth control throughout the study (barrier and/or oral contraceptives)

- Current psychotic symptoms

- An increased risk of seizure, determined by history

- Medications judged to notably affect cortical excitability e.g., anticonvulsants or
high-dose benzodiazepines (> 4 mg/day of clonazepam or equivalent)

- Predominant hoarding symptoms
We found this trial at
1
site
345 Blackstone Blvd
Providence, Rhode Island 02906
(401) 455-6200
Phone: 401-455-6602
Butler Hospital Founded in 1844, Butler Hospital is the state's only non-profit, free-standing psychiatric hospital...
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mi
from
Providence, RI
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