A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome
| Status: | Recruiting |
|---|---|
| Conditions: | Anemia |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 6 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | February 2016 |
| Contact: | Suvankar Majumdar, MD |
| Email: | smajumdar@umc.edu |
| Phone: | 6019845220 |
A Phase 1 Dose Escalation Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome
Sickle cell disease is a genetic red blood cell disorder characterized by vaso-occlusion
from sickling of red blood cells, that can lead to pain or organ complications such as acute
chest syndrome. Sickle cell disease is associated with low amounts of nitric oxide, a
compound important for dilating the blood vessel wall. Citrulline is a substance that is
known to increase nitric oxide. The goal of this Phase I study are to find the highest safe
dose of continuous IV citrulline that can be given to individuals with sickle cell disease
experiencing a sickle cell pain crisis or acute chest syndrome without causing severe side
effects.
from sickling of red blood cells, that can lead to pain or organ complications such as acute
chest syndrome. Sickle cell disease is associated with low amounts of nitric oxide, a
compound important for dilating the blood vessel wall. Citrulline is a substance that is
known to increase nitric oxide. The goal of this Phase I study are to find the highest safe
dose of continuous IV citrulline that can be given to individuals with sickle cell disease
experiencing a sickle cell pain crisis or acute chest syndrome without causing severe side
effects.
Inclusion Criteria:
1. Sickle cell disease genotypes (HbSS, HbS/β0-thalassemia, HbS/β+-thalassemia, HbSC)
2. Ages 6 to 50 years old
3. Patients with sickle cell disease aged 6 to 50 years old Presence of sickle cell pain
crisis defined by the presence of pain requiring hospitalization and parental opioid
therapy
4. Presence of acute chest syndrome defined by the presence of a new CXR infiltrate and
any one of the following respiratory symptoms of fever, shortness of breath,
wheezing, chest pain, cough or new onset hypoxia.
Exclusion Criteria:
1. Presence of any other complication related to sickle cell disease requiring
hospitalization such as splenic sequestration, hepatic sequestration, stroke,
avascular necrosis of the hip/shoulder, acute priapism, etc.
2. Severe anemia (hemoglobin < 5g/dL)
3. History of red blood cell transfusion within the last 30 days
4. Systemic steroid therapy within the last 48 hours
5. Pregnant (as confirmed by a negative urine pregnancy test) or lactating female
6. Alanine/aspartate transferase >2x upper limit of normal laboratory range for age.
7. Subject has the following serum creatinine:
- Age 6 to 13 years > 0.9 mg/dL
- Age 14-17 years 1.0 mg/dL
- Age 18 years >1.5mg/dL
8. Patients with an inability to give consent will be excluded
We found this trial at
1
site
2500 N State St
Jackson, Mississippi 39216
Jackson, Mississippi 39216
(601) 984-1000
Phone: 601-984-5200
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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