Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications
| Status: | Recruiting |
|---|---|
| Conditions: | Anxiety, Anxiety, Depression, Anemia |
| Therapuetic Areas: | Hematology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2015 |
| Contact: | Charles Jonassaint, PhD |
| Email: | jonassaintcr@upmc.edu |
| Phone: | 4125869850 |
Feasibility of Implementing Mental Health Treatment in Routine Adult Sickle Cell Disease Care Using Online Cognitive Behavioral Therapy and a Mobile Technology-Based Intervention
Patients with sickle cell disease (SCD) experience significant depressive symptoms that
currently go unrecognized and under-treated. Further, depression in this patient population
has the potential to contribute to high health care utilization and poor disease outcomes;
however, there are currently no comparative effectiveness studies of evidenced-based mental
health treatments for depression in SCD.
The primary objective of this study is to test the effectiveness of an online computerized
cognitive behavioral therapy intervention to address psychological and behavioral needs of
patients with sickle cell disease, namely depression and pain symptoms. The investigators
will implement an existing computerized cognitive behavioral therapy (CCBT) program called
"Beating the Blues" into routine clinical care at the University of Pittsburgh Medical
Center (UPMC) Adult Sickle Cell Clinic to determine the effectiveness of this intervention
in decreasing depression and pain versus treatment as usual. Patients with significant
distress—depression and/or anxiety symptoms—will be randomized to either eight sessions of a
CCBT program and weekly follow-up with a care manager or treatment as usual where the
treating physician is notified of the patient's symptoms. The investigators will evaluate
patient acceptability, implementation and practicality of the online mental health
intervention through patient use of the site (frequency and duration of visits), qualitative
interviews, and surveys. The investigators hypothesize: 1) the CCBT will be an acceptable
mental health treatment for patients and easily integrated into routine clinical care; 2)
patients in the treatment arm will show a greater decrease in depression/anxiety symptoms
and average daily pain than patients in usual care.
currently go unrecognized and under-treated. Further, depression in this patient population
has the potential to contribute to high health care utilization and poor disease outcomes;
however, there are currently no comparative effectiveness studies of evidenced-based mental
health treatments for depression in SCD.
The primary objective of this study is to test the effectiveness of an online computerized
cognitive behavioral therapy intervention to address psychological and behavioral needs of
patients with sickle cell disease, namely depression and pain symptoms. The investigators
will implement an existing computerized cognitive behavioral therapy (CCBT) program called
"Beating the Blues" into routine clinical care at the University of Pittsburgh Medical
Center (UPMC) Adult Sickle Cell Clinic to determine the effectiveness of this intervention
in decreasing depression and pain versus treatment as usual. Patients with significant
distress—depression and/or anxiety symptoms—will be randomized to either eight sessions of a
CCBT program and weekly follow-up with a care manager or treatment as usual where the
treating physician is notified of the patient's symptoms. The investigators will evaluate
patient acceptability, implementation and practicality of the online mental health
intervention through patient use of the site (frequency and duration of visits), qualitative
interviews, and surveys. The investigators hypothesize: 1) the CCBT will be an acceptable
mental health treatment for patients and easily integrated into routine clinical care; 2)
patients in the treatment arm will show a greater decrease in depression/anxiety symptoms
and average daily pain than patients in usual care.
Inclusion Criteria:
1. Male or female ≥18 years of age at baseline visit.
2. Documentation of a SCD diagnosis (HgbSS, HgbSC, SBeta +Thal; or SBeta oThal)
3. Receive routine care at the UPMC sickle cell clinic.
4. Scores indicative of clinically significant depression or anxiety on the stress/pain
screener that is administered as part of routine SCD care to all patients. i.e.
Patient Health Questionnaire (PHQ-9) ≥ 10 and/or Generalized Anxiety Disorder scale
(GAD-7) ≥ 8
Exclusion Criteria:
1. Presence of a condition or abnormality (e.g. significant neurocognitive dysfunction)
that in the opinion of the Investigator would compromise the safety of the patient or the
quality of the data.
We found this trial at
1
site
4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
Pittsburgh, Pennsylvania 15260
(412) 624-4141
Principal Investigator: Charles Jonassaint, PhD
Phone: 412-586-9850
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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