Zimura in Subjects With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration



Status:Active, not recruiting
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:11/11/2018
Start Date:January 2016

Use our guide to learn which trials are right for you!

A Phase 2b Randomized, Double-Masked, Controlled Trial to Assess the Safety and Efficacy of Intravitreous Administration of Zimura™ (Anti-C5 Aptamer) in Subjects With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration

The objectives of this study are to evaluate the safety and efficacy of intravitreous
administration of Zimura when administered in subjects with geographic atrophy (GA) secondary
to dry age-related macular degeneration (AMD).

Part 1: Approximately 66 subjects will be randomized in a 1:1:1 ratio to the following dose
groups:

- Zimura Dose Administration 1

- Zimura Dose Administration 2

- Sham Administration 1

Part 2: Approximately 135 subjects will be randomized in a 1:2:2 ratio to the following dose
groups:

- Zimura Dose Administration 3

- Zimura Dose Administration 4

- Sham Administration 2

Subjects will receive monthly intravitreal injections of Zimura or Sham for 18 months.

Inclusion Criteria:

- Subjects of either gender aged ≥ 50 years

- Diagnosis of Non-foveal GA secondary to dry AMD

Exclusion Criteria:

- Evidence of Choroidal Neovascularization (CNV)

- GA secondary to any condition other than AMD

- Any prior treatment for AMD or any prior intravitreal treatment for any indication in
either eye, except oral supplements of vitamins and minerals

- Any intraocular surgery or thermal laser within three (3) months of trial entry

- Any prior thermal laser in the macular region, regardless of indication

- Any ocular or periocular infection in the twelve (12) weeks

- Previous therapeutic radiation in the region of the study eye

- Any sign of diabetic retinopathy in either eye
We found this trial at
52
sites
218
mi
from 91732
Henderson, NV
Click here to add this to my saved trials
98-1079 Moanalua Road
'Aiea, Hawaii 96701
2575
mi
from 91732
'Aiea, HI
Click here to add this to my saved trials
1060
mi
from 91732
Abilene, TX
Click here to add this to my saved trials
Altamonte Springs, Florida 32701
2181
mi
from 91732
Altamonte Springs, FL
Click here to add this to my saved trials
922
mi
from 91732
Amarillo, TX
Click here to add this to my saved trials
2002
mi
from 91732
Asheville, NC
Click here to add this to my saved trials
2053
mi
from 91732
Augusta, GA
Click here to add this to my saved trials
1213
mi
from 91732
Austin, TX
Click here to add this to my saved trials
2301
mi
from 91732
Baltimore, MD
Click here to add this to my saved trials
2578
mi
from 91732
Boston, MA
Click here to add this to my saved trials
2309
mi
from 91732
Boynton Beach, FL
Click here to add this to my saved trials
313
mi
from 91732
Campbell, CA
Click here to add this to my saved trials
Charlotte, North Carolina 28207
2102
mi
from 91732
Charlotte, NC
Click here to add this to my saved trials
2278
mi
from 91732
Chevy Chase, MD
Click here to add this to my saved trials
1880
mi
from 91732
Cincinnati, OH
Click here to add this to my saved trials
2032
mi
from 91732
Cleveland, OH
Click here to add this to my saved trials
817
mi
from 91732
Denver, CO
Click here to add this to my saved trials
207
mi
from 91732
Fresno, CA
Click here to add this to my saved trials
13
mi
from 91732
Fullerton, CA
Click here to add this to my saved trials
1840
mi
from 91732
Grand Rapids, MI
Click here to add this to my saved trials
1206
mi
from 91732
Grapevine, TX
Click here to add this to my saved trials
2069
mi
from 91732
Hickory, NC
Click here to add this to my saved trials
1357
mi
from 91732
Houston, TX
Click here to add this to my saved trials
99
mi
from 91732
La Jolla, CA
Click here to add this to my saved trials
2171
mi
from 91732
Ladson, SC
Click here to add this to my saved trials
1908
mi
from 91732
Marietta, GA
Click here to add this to my saved trials
2239
mi
from 91732
Melbourne, FL
Click here to add this to my saved trials
Mountain View, California 94040
323
mi
from 91732
Mountain View, CA
Click here to add this to my saved trials
?
mi
from 91732
Osijek,
Click here to add this to my saved trials
2375
mi
from 91732
Philadelphia, PA
Click here to add this to my saved trials
343
mi
from 91732
Phoenix, AZ
Click here to add this to my saved trials
827
mi
from 91732
Portland, OR
Click here to add this to my saved trials
48
mi
from 91732
Redlands, CA
Click here to add this to my saved trials
387
mi
from 91732
Reno, NV
Click here to add this to my saved trials
2267
mi
from 91732
Richmond, VA
Click here to add this to my saved trials
2245
mi
from 91732
Rochester, NY
Click here to add this to my saved trials
364
mi
from 91732
Sacramento, CA
Click here to add this to my saved trials
Saint Petersburg, Florida 33713
2130
mi
from 91732
Saint Petersburg, FL
Click here to add this to my saved trials
570
mi
from 91732
Salt Lake City, UT
Click here to add this to my saved trials
24
mi
from 91732
Santa Ana, CA
Click here to add this to my saved trials
1335
mi
from 91732
Shawnee Mission, KS
Click here to add this to my saved trials
Springfield, Massachusetts 01199
2501
mi
from 91732
Springfield, MA
Click here to add this to my saved trials
2280
mi
from 91732
Stuart, FL
Click here to add this to my saved trials
2319
mi
from 91732
Syracuse, NY
Click here to add this to my saved trials
1344
mi
from 91732
The Woodlands, TX
Click here to add this to my saved trials
427
mi
from 91732
Tucson, AZ
Click here to add this to my saved trials
West Columbia, South Carolina 29169
2103
mi
from 91732
West Columbia, SC
Click here to add this to my saved trials
1415
mi
from 91732
West Des Moines, IA
Click here to add this to my saved trials
2126
mi
from 91732
West Mifflin, PA
Click here to add this to my saved trials
1182
mi
from 91732
Wichita, KS
Click here to add this to my saved trials
1355
mi
from 91732
Willow Park, TX
Click here to add this to my saved trials
2176
mi
from 91732
Winter Haven, FL
Click here to add this to my saved trials