Exploratory Study of Relationships Between Malodor and Urine Metabolomics
| Status: | Completed |
|---|---|
| Conditions: | Food Studies, Endocrine |
| Therapuetic Areas: | Endocrinology, Pharmacology / Toxicology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/21/2018 |
| Start Date: | February 2016 |
| End Date: | May 2018 |
Metabolomic Profiling of Urine Samples for the Identification of Novel Biomarkers and Mechanisms in the Diagnosis and Management of Malodor Associated With Metabolic Inefficiencies
The purpose of this study is to identify metabolic signatures associated with malodor
conditions. The investigators will perform state-of-the art metabolomics tests and
bioinformatic data mining to explore if conditions leading to malodor can be screened by
metabolomic profiling of urine samples.
conditions. The investigators will perform state-of-the art metabolomics tests and
bioinformatic data mining to explore if conditions leading to malodor can be screened by
metabolomic profiling of urine samples.
In this study, metabolite profiling analysis will be carried out on urine samples of
individuals with malodor conditions related to metabolism inefficiencies. Metabolic profiles
will be identified using the metabolomics equipment located in the NMR, HPLC and MS
facilities of the Metabolomics Innovation Centre (TMIC). Multivariate statistical analyses
will be used, as well as other approaches to mine complex data from heterogeneous sources.
individuals with malodor conditions related to metabolism inefficiencies. Metabolic profiles
will be identified using the metabolomics equipment located in the NMR, HPLC and MS
facilities of the Metabolomics Innovation Centre (TMIC). Multivariate statistical analyses
will be used, as well as other approaches to mine complex data from heterogeneous sources.
Inclusion Criteria:
- 18 years or older
- unpredictable and uncontrollable episodes of malodor
- willing and able to ship a urine sample (in the kit provided) by an overnight courier
to Edmonton, Alberta, Canada
- good general health
Exclusion Criteria:
- serious medical conditions that require treatment
- conditions that, in the opinion of the investigator, would prevent participation
- under the age of 18
- elect not to participate in the study
We found this trial at
2
sites
Miami, Florida 33175
Principal Investigator: Irene Gabashvili, PhD
Phone: 786-228-6880
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