Air Pollution Study: The Effect of Ozone on the Lung
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 10/17/2018 |
| Start Date: | January 2016 |
| End Date: | January 2020 |
| Contact: | Kathy Black, PhD |
| Email: | kgblack@eohsi.rutgers.edu |
| Phone: | 848-445-6049 |
Activated Macrophages and Ozone Toxicity
The purpose of the study is to better understand the mechanisms of lung injury from ozone
exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone.
Subjects will be asked to produce sputum through coughing after each exposure. The samples
will be analyzed for macrophage activity.
exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone.
Subjects will be asked to produce sputum through coughing after each exposure. The samples
will be analyzed for macrophage activity.
Subjects will be asked to come to the Rutgers EOHSI clinical center (Piscataway, NJ) for 5
study visits. A physical exam to determine eligibility will be done at the first study visit.
If the subject is healthy and able to produce a sputum sample, he/she will then be scheduled
for 2 3-hour exposure visits. One exposure will be to clean air and the other exposure will
be to 0.2 ppm ozone. During the exposures, subjects will be requested to ride an exercise
bicycle intermittently (approximately every 15 minutes). A follow-up visit for sputum
collection will be scheduled either 24, 48, or 72 hours after each exposure visit. Blood,
urine, and exhaled breath samples will also be collected at each visit.
study visits. A physical exam to determine eligibility will be done at the first study visit.
If the subject is healthy and able to produce a sputum sample, he/she will then be scheduled
for 2 3-hour exposure visits. One exposure will be to clean air and the other exposure will
be to 0.2 ppm ozone. During the exposures, subjects will be requested to ride an exercise
bicycle intermittently (approximately every 15 minutes). A follow-up visit for sputum
collection will be scheduled either 24, 48, or 72 hours after each exposure visit. Blood,
urine, and exhaled breath samples will also be collected at each visit.
Inclusion Criteria:
- Healthy men and women
Exclusion Criteria:
- Cardiovascular disease
- Respiratory disease
- Diabetes
- Pregnancy
- HIV infection
- History of smoking within the last 5 years
- Daily use of antioxidant supplements (e.g., Vitamin C/E, selenium, beta-carotene,
lycopene, lutein, zeaxanthin, or ginkgo biloba)
- Orthopedic or rheumatological conditions that would interfere with cycle use
We found this trial at
1
site
Piscataway, New Jersey 08854
Phone: 848-445-6049
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