A Study of Safety, Pharmacokinetics, Pharmacodynamics of JNJ-61610588 in Participants With Advanced Cancer

The purpose of this study is to see if JNJ-61610588 is safe and useful for treating
participants with advanced cancer. This study consists of up to 4 parts. Part 1 will
determine what dose of JNJ-61610588 can be given safely to advanced cancer participants. Part
2 will look at how participants with metastatic non-small cell lung cancer respond to a safe
dose of JNJ-61610588. Parts 3 and 4 will test whether the dose of JNJ-61610588 identified in
Part 1 is a safe and effective therapy for participants with specific types of advanced
cancers (lung, pancreas, cervical, colorectal, head and neck). Participants will receive
study drug in an outpatient setting. Participants safety will be monitored throughout the
study.

Inclusion Criteria:

- The participant has a solid tumor. Parts 2 and 3 are limited to participants with
non-small cell lung cancer. Part 4 is limited to participants with small cell lung,
head and neck, pancreatic, colorectal, and cervical cancers

- Tumor progression following at least one prior standard therapy

- The participant has a radiographically measurable tumor. Evaluable disease is
acceptable for Part 1 only

- The participant is willing to consent to provide a tumor tissue sample (fresh biopsy)
before (Parts 2 and 3) and after (Part 2 only) receiving the study drug

- The participant is able to carry out daily life activities without difficulty

- The participant does not have significant side effects from previous anti-cancer
treatment

- The participant has adequate organ and blood cell counts

- Sexually active participants must use medically acceptable methods of contraception
during the course of this study

Exclusion Criteria:

- The participant has a history of major surgery or treatment other cancer therapy
within 2-6 weeks before starting the study

- The participant has an untreated brain tumor

- Current severe, uncontrolled systemic disease including an ongoing, active infection
requiring treatment with antibiotics

- The participant has high blood pressure or diabetes that is not well-controlled with
medication

- History of clinically significant heart problems

- History of severe side effects toimmunotherapy

- The participant is pregnant, breastfeeding, or planning to become pregnant or father a
child

- Positive for Hepatitis B, Hepatitis C, or HIV

- The participant has received anticoagulant therapy with the exception of aspirin
within 1 week of starting the study