Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers

Inclusion Criteria:

1. Healthy men and women;

2. Age 18 to 60 years, inclusive;

3. Weight ≥ 50 kg and Body Mass Index (BMI) of 19 to 32, inclusive;

4. Female subjects must be of non-childbearing potential;

5. Male subjects must agree to use a double barrier method of birth control;

6. Signed informed consent form (ICF) prior to study procedures.

Exclusion Criteria:

1. Current or recent (within 14 days of Day 0) bacterial or viral infection;

2. Positive results at screening for hepatitis B surface antigen, hepatitis C antibody,
or HIV antibody;

3. Clinically significant abnormalities noted on ECG;

4. Safety laboratory abnormalities;

5. Regular use of medications, prescription or non-prescription;

6. Poor vein access or fear of venipuncture or sight of blood;

7. Major surgery, significant recent injury or trauma within 30 days;

8. Received an investigational drug or vaccine within 30 days.