Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis



Status:Completed
Conditions:Other Indications, Gastrointestinal
Therapuetic Areas:Gastroenterology, Other
Healthy:No
Age Range:2 - 17
Updated:4/17/2018
Start Date:April 2016
End Date:March 2018

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A Randomized Pilot Trial of Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis

The goal of this study is to compare the efficacy of PVI irrigation to no irrigation for
decreasing postoperative intra-abdominal abscesses in children with perforated appendicitis.
Additionally, this study aims to verify the safety profile of dilute PVI for intra-abdominal
irrigation.

Postoperative intra-abdominal abscesses are common occurrences after perforated appendicitis
in pediatric patients despite utilization of evidence-based practices. Povidone-iodine is a
commonly used antiseptic in surgical procedures and has been shown to be effective in
reducing postoperative abscesses in adults with perforated appendicitis. This trial will be
the first to rigorously test the efficacy of povidone-iodine irrigation in children and to
verify its safety profile in this patient population.

Inclusion Criteria:

- Children who undergo an appendectomy for perforated appendicitis. (Appendicitis:
Diagnosis is made intraoperatively by the surgeon. Diagnosis Method: The visualization
of a gross defect in the appendiceal wall or the presence of intraperitoneal stool or
a fecalith at the time of operation.)

Exclusion Criteria:

- Patients presenting with simple or gangrenous appendicitis

- Patients with a history of iodine sensitivity, thyroid disease or renal disease

- Patients undergoing interval or incidental appendectomy

- Patients/parents/legal guardians who are both non-English and non-Spanish speaking
We found this trial at
1
site
7000 Fannin St
Houston, Texas 77030
(713) 500-4472
Phone: 713-500-7300
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
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mi
from
Houston, TX
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