A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease



Status:Recruiting
Conditions:Prostate Cancer, Cancer, Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases, Oncology
Healthy:No
Age Range:Any
Updated:3/30/2019
Start Date:April 2016
End Date:July 2021
Contact:Global Clinical Compliance
Email:DK0-Disclosure@ferring.com

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A Multi-Center, Randomized, Assessor-Blind, Controlled Trial Comparing the Occurrence of Major Adverse Cardiovascular Events (MACEs) in Patients With Prostate Cancer and Cardiovascular Disease Receiving Degarelix (Gonadotropin-Releasing Hormone (GnRH) Receptor Antagonist) or Leuprolide (GnRH Receptor Agonist)

The purpose of this trial is to test if a marketed drug for advanced prostate cancer
(FIRMAGON) can reduce the risk of cardiovascular complications as compared to another
marketed drug for advanced prostate cancer (LUPRON DEPOT) in patients with prostate cancer
and cardiovascular disease.


Inclusion Criteria:

- Advanced prostate cancer

- Indication to initiate androgen deprivation therapy (ADT)

- Predefined cardiovascular disease

Exclusion Criteria:

- Previous or current hormonal management of prostate cancer (unless terminated at least
12 months prior to trial)

- Acute cardiovascular disease in the previous 30 days
We found this trial at
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Shreveport, Louisiana 71106
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6719 Alvarado Road
San Diego, California 92120
619-287-6000
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47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
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Albuquerque, New Mexico 87109
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Anaheim, California 92801
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Anchorage, Alaska 99508
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1 Presidential Boulevard
Bala-Cynwyd, Pennsylvania 19004
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Birmingham, Alabama 35209
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Bronx, New York 10467
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Burien, Washington 98166
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Charleston, South Carolina 29425
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Chattanooga, Tennessee 37403
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Concord, North Carolina 28025
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Dallas, Texas 75231
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Denver, Colorado 80211
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Greenwood, Indiana 46143
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Jeffersonville, Indiana 47130
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Kansas City, Missouri 64128
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Kelowna, British Columbia
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Lancaster, Pennsylvania 17604
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Lawrenceville, New Jersey
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Lenexa, Kansas 66214
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Lincoln, California 95648
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Little Rock, Arkansas 72211
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Miami Beach, Florida 33140
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Middleburg Heights, Ohio 44130
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8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
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Mount Laurel, New Jersey
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1430 Tulane Ave Suite SL32
New Orleans, Louisiana 70112
(504) 588-5912
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New York, New York 10016
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1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Norfolk, Virginia 23502
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101 The City Drive South
Orange, California 92868
714-456-7890
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Pompano Beach, Florida 33060
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Poughkeepsie, New York 12601
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Richmond, Virginia 23235
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Salisbury, North Carolina 28144
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San Luis Obispo, California 93401
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Springfield, Illinois 62703
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Springfield, Oregon 97477
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9040 Jackson Ave
Tacoma, Washington 98431
(253) 968-1110
Madigan Army Medical Center Located on Joint Base Lewis-McChord, Madigan Army Medical Center comprises a...
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Tampa, Florida 33607
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Torrance, California 90505
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Towson, Maryland 21204
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Tucson, Arizona 85715
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Washington, District of Columbia 20036
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Wellington, Florida 33449
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West Des Moines, Iowa 50266
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Whittier, California 90603
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1901 S Hawthorne Rd #306
Winston-Salem, North Carolina 27103
(336) 768-8062
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