Analgesic Efficacy of Liposomal Bupivacaine vs. Bupivacaine HCL as a Tap Block After Abdominally Based Autologous Breast Reconstruction
| Status: | Terminated |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/20/2019 |
| Start Date: | February 29, 2016 |
| End Date: | March 8, 2018 |
A Prospective Trial to Assess Analgesic Efficacy of Liposomal Bupivacaine vs. Bupivacaine HCL as a Tap Block After Abdominally Based Autologous Breast Reconstruction
This study will evaluate the efficacy of analgesia provided by liposomal bupivacaine
(Exparel) when compared to bupivacaine HCL as a transverse abdominis plane (TAP) block in
terms of discharge milestones, opioid use, costs, and patient-reported satisfaction at 12,
24, and 72 hours. The investigators propose that Exparel will lower opioid use, length of
stay, and overall cost of abdominally-based autologous breast reconstruction, and will lead
to greater patient satisfaction.
(Exparel) when compared to bupivacaine HCL as a transverse abdominis plane (TAP) block in
terms of discharge milestones, opioid use, costs, and patient-reported satisfaction at 12,
24, and 72 hours. The investigators propose that Exparel will lower opioid use, length of
stay, and overall cost of abdominally-based autologous breast reconstruction, and will lead
to greater patient satisfaction.
Inclusion Criteria:
- Scheduled for abdominal-based autologous breast reconstruction (DIEP, MS-TRAM, or
TRAM).
- At least 18 years of age.
- Female.
- Able to understand and willing to sign a written informed consent document.
Exclusion Criteria:
- Cognitive impairment.
- History of abdominal surgery precluding free flap donor site.
- Allergy or intolerance to bupivacaine or "amide" anesthetics.
- Significant preoperative chronic pain (requiring daily narcotics) or neuropathic pain
(requiring daily use of pregabalin or gabapentin) within the previous 3 months.
- Pregnant or breastfeeding.
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Terence Myckatyn, M.D.
Phone: 314-996-8800
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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