CAP-Ketamine for Antidepressant Resistant PTSD



Status:Recruiting
Conditions:Psychiatric, Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 70
Updated:1/23/2019
Start Date:April 18, 2016
End Date:September 30, 2019
Contact:Lynnette Averill
Email:Lynnette.Averill@va.gov

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as
compared to placebo, in reducing symptoms of Posttraumatic Stress Disorder (PTSD) in an
active duty military and Veteran population.

In this 2-site clinical trial, intended to evaluate the safety and efficacy of repeated doses
of ketamine for treatment resistant PTSD, Veterans and active duty military personnel who
meet criteria for PTSD and the additional inclusion and exclusion criteria will be randomized
to one of three treatment arms (placebo, low dose ketamine, high dose ketamine). Participants
receive the study drug via intravenous infusion twice per week for 4-weeks.

Inclusion Criteria:

- male or female Veterans or active duty military personnel between the ages of 18 and
70 years

- diagnosis of PTSD

- history of trialing one or more antidepressant medications with little to no PTSD
symptom improvement

- ability to provide written informed consent

Exclusion Criteria:

- females who are currently pregnant or breastfeeding

- current risk for suicide

- history of severe head injury
We found this trial at
2
sites
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
West Haven, Connecticut 06516
Principal Investigator: John H. Krystal, MD
Phone: 203-932-5711
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West Haven, CT
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Brooke Army Medical Center
San Antonio, Texas 78234
Phone: 210-539-9422
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San Antonio, TX
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