Oxidative Stress in OR Personnel



Status:Withdrawn
Conditions:Other Indications
Therapuetic Areas:Other
Healthy:No
Age Range:Any
Updated:1/27/2018
Start Date:May 2014
End Date:March 2016

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Oxidative Stress Status During Anesthesia in Pediatric Surgical Room Staff Versus Non-operating Room Personnel: Pilot Study

The purpose of this study is investigate to the effect(s) of chronic occupational exposure to
N20 and volatile anesthetics on the extent of oxidative stress (DNA damage and the generation
of the biochemical markers) in operating room staff, with different levels of exposure to
halogenated hydrocarbons, in comparison to unexposed controls (Intensive Care Staff), and to
determine the relationship between the degree of oxidative stress and psychological stress,
as assessed by validated psychometric measures.

This is a single blinded randomized, controlled and prospective clinical trial comparing
oxidative stress status in two groups.

Subjects in two groups will be matched for gender, age, smoking habit and employment duration
and will be randomized into one of the two groups of:

1. Pediatric OR Staff, and

2. control (e.g; ICU staff)

Biomarkers of oxidative stress will be measured in two different time points in each subject,
(Monday Morning and, Friday afternoon of that same week->40 hours in Operating room or
Intensive Care Unit).

The relationship between oxidative stress and psychological stress will also be assessed by
validated psychometric measures.

Inclusion Criteria:

1. CHOR-Staff who work > 40 hours per week in the operating rooms (Anesthesiologists,
CRNA, Surgeons, Nurses)

2. NOR- Intensive Care Unit Staff who work > 40 hours per week in Intensive care unit
(Physicians, Nurses, APN'S)

Exclusion Criteria:

Staff with the following history will be excluded:

1. Therapeutic exposure to radiation

2. On chemotherapeutic agents

3. History of General Anesthesia during the past two years
We found this trial at
1
site
700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
Phone: 614-722-4200
Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
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Columbus, OH
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