A Study of Rituximab Versus Iodine I 131 Tositumomab Therapy for Patients With Non-Hodgkin's Lymphoma
| Status: | Recruiting |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | April 2004 |
A Multi-Center, Randomized, Phase III Study of Rituximab Versus Iodine I 131 Tositumomab Therapy for Patients With Relapsed Follicular Non-Hodgkin's Lymphoma
A total of 506 patients, 253 per arm, will be enrolled at 30 to 40 sites in the United
States and Europe.
Patients will be randomly assigned to one of two treatment arms. In Arm A, patients will
receive 375 mg/m2 of rituximab (US, Canada – Rituxan®; EU - Mabthera®), given as an IV
infusion once weekly for 4 weeks. In Arm B, patients will receive Iodine I 131 Tositumomab
therapy. For Arm B, patients undergo a two-phase treatment. In the first phase, termed the
“dosimetric dose,” patients will receive an infusion of unlabeled Tositumomab (450 mg)
immediately followed by an infusion of Tositumomab (35 mg) that has been labeled with 5 mCi
(0.18 GBq) of iodine 131. Whole body gamma camera scans will be obtained three times (Day 0,
Day 2, 3, or 4, and Day 6 or 7) following the dosimetric dose. Using the dosimetric data
from these three imaging timepoints, the patient’s weight, and platelet count, a
patient-specific administered activity of iodine I 131 Tositumomab (expressed in mCi or GBq)
will be calculated to deliver the desired total body dose of radiation (65 or 75 cGy). In
the second phase, termed the “therapeutic dose,” patients in Arm B will receive an infusion
of unlabeled Tositumomab (450 mg) immediately followed by an infusion of the
patient-specific administered activity of Iodine 131–conjugated Tositumomab (35 mg).
Patients on study will be followed for response and safety at Week 7, Week 13, and every 3
months for the first and second years, every 6 months for the third year, and then annually
for the fourth and fifth years. Patients will be followed for safety only annually for years
6-10.
States and Europe.
Patients will be randomly assigned to one of two treatment arms. In Arm A, patients will
receive 375 mg/m2 of rituximab (US, Canada – Rituxan®; EU - Mabthera®), given as an IV
infusion once weekly for 4 weeks. In Arm B, patients will receive Iodine I 131 Tositumomab
therapy. For Arm B, patients undergo a two-phase treatment. In the first phase, termed the
“dosimetric dose,” patients will receive an infusion of unlabeled Tositumomab (450 mg)
immediately followed by an infusion of Tositumomab (35 mg) that has been labeled with 5 mCi
(0.18 GBq) of iodine 131. Whole body gamma camera scans will be obtained three times (Day 0,
Day 2, 3, or 4, and Day 6 or 7) following the dosimetric dose. Using the dosimetric data
from these three imaging timepoints, the patient’s weight, and platelet count, a
patient-specific administered activity of iodine I 131 Tositumomab (expressed in mCi or GBq)
will be calculated to deliver the desired total body dose of radiation (65 or 75 cGy). In
the second phase, termed the “therapeutic dose,” patients in Arm B will receive an infusion
of unlabeled Tositumomab (450 mg) immediately followed by an infusion of the
patient-specific administered activity of Iodine 131–conjugated Tositumomab (35 mg).
Patients on study will be followed for response and safety at Week 7, Week 13, and every 3
months for the first and second years, every 6 months for the third year, and then annually
for the fourth and fifth years. Patients will be followed for safety only annually for years
6-10.
Inclusion Criteria
- A histologically confirmed diagnosis of follicular lymphoma, Grade I, II, or III
(WHO/REAL Classification) (follicular, small cleaved; follicular, mixed small-cleaved
and large-cell; or follicular large-cell lymphoma in the International Working
Formulation).
- Recurrent lymphoma after one or two qualifying therapy regimen(s).
- A performance status of at least 70% on the Karnofsky Scale.
- An absolute neutrophil count > 1500 cells/mm3 and a platelet count > 100,000
cells/mm3.
- Adequate renal function and adequate hepatic function.
- Bi-dimensionally measurable disease with at least one lesion measuring > or equal to
2.0 x 2.0 cm (i.e., > 4.0 cm2) by CT scan.
- HAMA negative.
- At least 18 years of age.
- Give written informed consent by signing an IRB/ethics committee approved informed
consent form prior to study entry.
Exclusion Criteria
- Histological transformation to diffuse,large cell lymphoma
- More than 1 course of rituximab
- Disease better treated with limited field therapy
- Involvement of >25% of the intratrabecular marrow
- Active infection
- Significant cardiac disease
- Prior ChemoRx, biological therapy, radiation Rx, or high dose systemic steroid
therapy within 8 weeks
- Prior radioimmunotherapy
- History of another malignancy
- HBsAg positivity
- CNS involvement with lymphoma
- Pregnant or nursing
- Ascites by physical exam
- Previous use of non-human monoclonal antibody therapy, known hypersensitive to murine
proteins
- Hydronephrosis
- Radiotherapy to >25% of the blood forming marrow
- Prior stem cell transplant
- Failed stem cell harvest
We found this trial at
5
sites
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Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Madigan Army Medical Center Located on Joint Base Lewis-McChord, Madigan Army Medical Center comprises a...
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