DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas



Status:Recruiting
Conditions:Lymphoma, Lymphoma, Psychiatric
Therapuetic Areas:Oncology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:10/7/2018
Start Date:October 2015
End Date:October 2019
Contact:Anita Kumar, MD
Phone:212-639-2668

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The purpose of this study is to determine whether a blood test can accurately detect whether
if the participant's lymphoma has come back after completion of initial chemotherapy
treatment for their aggressive B-cell Non-Hodgkin lymphoma. The purpose of the study is to
see if MRD in blood samples can potentially replace CT scans after completion of chemotherapy
in the future.


Inclusion Criteria:

- 18 years of age at time of signing informed consent

- Histology-confirmed aggressive B-cell Non-Hodgkin lymphoma

- De novo diffuse large B-cell lymphoma (including all subtypes such as primary
mediastinal B-cell lymphoma and T-cell rich B-cell lymphoma). According to the
2008 WHO Classification of Hematopoietic and Lymphoid Tumors. These would include
double or triple-hit diffuse large B-cell lymphomas with MYC/BCL2 and/or BCL6
gene rearrangements. These cases may be classified as high grade B-cell lymphomas
according to the 2017 revision of the WHO Classification of Hematopoietic and
Lymphoid Tumors.

- Recipient of frontline multi-agent chemotherapy (for example, RCHOP, dose
adjusted-REPOCH, RCHOP/RICE, RCHOP+investigational agent, etc). Eligible patients will
have recently received (≤ 4 months from end of treatment assessment), be actively
receiving, or planned to receive frontline chemotherapy in near future (within 3
months of signing consent). A frontline therapy program can include different
sequential phases of treatment, including high-dose therapy and autologous stem cell
transplantation.

- Required pre-treatment test specimen from bone marrow, blood, lymph node, or alternate
site to identify tumor-specific clonotype.

- Ability to adhere to the study visit schedule and all the protocol requirements,
including surveillance imaging and MRD test specimen collection at specified time
points.

Exclusion Criteria:

- Patients receiving 2nd or greater line of therapy.
We found this trial at
13
sites
225 Summit Avenue
Montvale, New Jersey 07645
Phone: 212-639-2668
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Miami, Florida 33124
(305) 284-2211
Principal Investigator: Izidore Lossos, MD
University of Miami A private research university with more than 15,000 students from around the...
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Basking Ridge, New Jersey 07920
Phone: 212-639-2668
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650 Commack Rd
Commack, New York 11725
(631) 623-4000
Phone: 212-639-2668
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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500 Westchester Avenue
Harrison, New York 10604
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500 Westchester Avenue
Harrison, New York 10604
Phone: 212-639-2668
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Houston, Texas 77030
Principal Investigator: Jason Westin, MD
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Middletown, New Jersey 07748
Phone: 212-639-2668
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Anita Kumar, MD
Phone: 212-639-2668
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Stephen Schuster, MD
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Rochester, Minnesota 55905
Principal Investigator: Grzegorz S. Nowakowski, MD
Phone: 507-284-2511
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Rockville Centre, New York 11570
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Sleepy Hollow, New York
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