Understanding How Ketamine Brings About Rapid Improvement in OCD

Therapuetic Areas:Psychiatry / Psychology
Age Range:18 - 65
Start Date:June 2016
End Date:June 2021
Contact:Jordan Wilson

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NMDAR Modulation As a Therapeutic Target and Probe of Neural Dysfunction in OCD

The purpose of this study is to understand how ketamine brings about rapid improvement in
Obsessive-Compulsive Disorder (OCD) symptoms.

Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the
economy over $2 billion annually and represents a significant public health problem. This
study aims to build on our discovery that a potent NMDA receptor antagonist, ketamine, has
rapid (in hours) and robust therapeutic effects in OCD. The proposed projects test the acute
mechanism of action of ketamine at the level of molecules, circuits, and network synchrony to
determine how NMDA receptor antagonism modifies the underlying pathology of OCD to relieve
repetitive thoughts and behaviors.

Inclusion Criteria for participants with OCD:

- age 18-65

- Primary diagnosis of OCD

- Sufficient severity of OCD symptoms

- ability to tolerate a treatment-free period

- capacity to provide informed consent

Inclusion criteria for healthy controls:

- ages 18-65

- capacity to provide informed consent

Exclusion criteria for participants with OCD:

- Psychiatric or medical conditions that make participation unsafe

- pregnant or nursing females

- concurrent use of any medications that might increase the risk of participation (e.g.
drug interactions)

- presence of metallic device or dental braces

Exclusion criteria for healthy controls:

- any current or lifetime psychiatric diagnosis

- pregnant or nursing females

- major medical or neurological problem

- presence of metallic device or dental braces
We found this trial at
450 Serra Mall
Stanford, California 94305
(650) 723-2300
Principal Investigator: Carolyn Rodriguez, MD, PhD
Phone: 650-723-4095
Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
Stanford, CA
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