Effects of HMB Supplementation on Recovery Following ACL Surgery
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 49 |
| Updated: | 3/15/2019 |
| Start Date: | November 2015 |
| End Date: | August 2017 |
Effects of HMB Supplementation on Muscle Mass Following ACL Reconstructive Surgery
The anterior cruciate ligament (ACL) is a primary stabilizer of the knee, and thus when ACL
injury occurs participation in physical activity is compromised. Reconstructive surgery is
often necessary to repair the damage which is then followed by a regimen of physical therapy
in order to regain full activity. Nutritional intervention after the surgery could help the
patient maintain muscle mass during recovery, thus allowing for a quicker return to normal
activity.
injury occurs participation in physical activity is compromised. Reconstructive surgery is
often necessary to repair the damage which is then followed by a regimen of physical therapy
in order to regain full activity. Nutritional intervention after the surgery could help the
patient maintain muscle mass during recovery, thus allowing for a quicker return to normal
activity.
Beta-hydroxy-beta-methylbutyrate (HMB) is a nutritional supplement shown to improve muscle
mass with exercise, and also in muscle loss conditions caused by a decrease in physical
activity. Participants will be recruited who will undergo reconstructive surgery for a
complete ACL tear and will then enter a standard physical therapy program during a six week
recovery period. Subjects will receive either HMB or a placebo supplement during the recovery
period. Muscle mass will be measured two weeks prior to the surgery and again after the
recovery period using an InBody 720 body composition analyzer. Additionally, the Knee Injury
and Osteoarthritis Outcome Score (KOOS) questionnaire will be administered as a measure of
recovery and activity level during the study.
mass with exercise, and also in muscle loss conditions caused by a decrease in physical
activity. Participants will be recruited who will undergo reconstructive surgery for a
complete ACL tear and will then enter a standard physical therapy program during a six week
recovery period. Subjects will receive either HMB or a placebo supplement during the recovery
period. Muscle mass will be measured two weeks prior to the surgery and again after the
recovery period using an InBody 720 body composition analyzer. Additionally, the Knee Injury
and Osteoarthritis Outcome Score (KOOS) questionnaire will be administered as a measure of
recovery and activity level during the study.
Inclusion Criteria:
- Complete anterior cruciate ligament (ACL) tear
- Will benefit from ACL reconstructive surgery
- Are able to participate in the physical therapy program
- No previous major knee injuries or surgeries
- No health conditions affecting muscle mass
Exclusion Criteria:
- Incomplete ACL tear
- Have multiple or bilateral ligament tears
- Are unable to participate in the physical therapy program
- Have had previous major knee injuries or surgeries
- Have health conditions affecting muscle mass
We found this trial at
1
site
Ames, Iowa 50010
Principal Investigator: Rick L Sharp, PhD
Phone: 515-294-8650
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