Neural Correlates of Working Memory Training for HIV Patients

The Overall Goals are to perform a double blind placebo-controlled study using Cogmed™ to
determine whether this adaptive WM training program will benefit HIV-infected individuals,
and whether the investigators can identify individuals who might benefit most from the
working memory (WM) training. Lastly, the investigators will explore how brain activation,
neuroinflammation and cerebrospinal fluid (CSF) monoamine levels might be related to WM
function before and after the training.

Inclusion Criteria for HIV-infected participants :

1. Men or women of any ethnicity, ages>18 years and able to provide informed consent,

2. HIV seropositive (with documentation from medical records),

3. Stable on an antiretroviral regimen for 6 months or will remain without antiretroviral
treatment during the duration of the study.

Inclusion Criteria for Seronegative (SN) healthy participants :

1. Men or women of any ethnicity, ages > 18 years and able to give informed consent,

2. Seronegative for HIV

Exclusion criteria :

1. Confounding co-morbid psychiatric illness

2. Confounding neurological disorders

3. Abnormal screening laboratory tests (>2 SD) that might indicate a chronic medical
condition (e.g. diabetes, severe cardiac, renal or liver disorders)

4. Medications that might influence outcome measures

5. Current or history of drug dependence within the past two years

6. Positive urine toxicology screen

7. Inability to read at an 8th grade level

8. Other contraindications for MR studies