Prehabilitation to Improve Functional and Clinical Outcomes in Patients With Aortic Stenosis



Status:Recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:60 - Any
Updated:8/17/2018
Start Date:October 2015
End Date:October 2019

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Trial Summary
Trial Overview
Inclusion Criteria

Prehabilitation to Improve Functional and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: TAVR-FRAILTY Trial

Transcatheter aortic valve replacement (TAVR) is a treatment alternative among high-risk
elderly with aortic stenosis, however, mortality remains high. Fifty percent of patients
undergoing TAVR exhibit frailty, a syndrome associated with poor survival. It is unknown
whether interventions to improve frailty before TAVR (prehabilitation) will improve outcomes
after TAVR. This study plans to evaluate whether simple cardiac exercise interventions to
improve physical performance before TAVR improves outcomes after TAVR.


Inclusion criteria:

- Eligibility for TAVR

- SPPB<9

- Able to exercise

- Able to come for follow-up visits

- Able to give informed consent

Exclusion criteria:

- New York Heart Association (NYHA) Class III/IV congestive heart failure (CHF)

- Presyncope or syncope as presentation

- Acute coronary syndrome

- Unable to exercise

- Dementia

- Sustained ventricular arrhythmia

- Stroke with neurological deficit

- Advanced Parkinson's

- Participated in an exercise program
We found this trial at
1
site
Mayo Clinic Rochester
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Phone: 507-255-5891
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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