Effects of Intranasal Oxytocin on Cigarette Smoking
| Status: | Recruiting |
|---|---|
| Conditions: | Smoking Cessation, Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/5/2019 |
| Start Date: | July 2016 |
| End Date: | July 2019 |
| Contact: | Ana Hilleboe |
| Email: | hilleboe@usc.edu |
| Phone: | (323) 442-2598 |
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural
processes that encode, interpret, and respond to socially and emotionally relevant stimuli)
have been implicated in tobacco smoking and relapse, however this potential target for
medication development has not been systematically examined. Evidence from animal and human
laboratories indicate that administration of intranasal oxytocin enhances socioemotional
processing and may be efficacious for the treatment of drug addiction, including nicotine
dependence. In order to evaluate the potential efficacy of intranasal oxytocin for smoking
cessation, this laboratory-based proposal will examine whether intranasal oxytocin attenuates
smoking lapse, nicotine withdrawal, and socioemotional processing disruptions in regular
smokers following overnight abstinence.
processes that encode, interpret, and respond to socially and emotionally relevant stimuli)
have been implicated in tobacco smoking and relapse, however this potential target for
medication development has not been systematically examined. Evidence from animal and human
laboratories indicate that administration of intranasal oxytocin enhances socioemotional
processing and may be efficacious for the treatment of drug addiction, including nicotine
dependence. In order to evaluate the potential efficacy of intranasal oxytocin for smoking
cessation, this laboratory-based proposal will examine whether intranasal oxytocin attenuates
smoking lapse, nicotine withdrawal, and socioemotional processing disruptions in regular
smokers following overnight abstinence.
Inclusion Criteria:
- Ages 18-40
- Smoke >= 10 cig/day for the past year
- English fluency
Exclusion Criteria:
- Current DSM-5 substance use disorder, excluding nicotine dependence (to minimize
alcohol or drug withdrawal symptoms during the study sessions)
- Any medical condition that would increase risk for study participation (such as sinus
infection or other condition blocking access to the olfactory epithelium)
- Women who are pregnant or nursing
- Current use of psychiatric medication
- Breath Carbon Monoxide (CO) levels < 10ppm measured during study intake (to exclude
individuals who overreport smoking in order to participate in the study)
- Planning to quit or reduce smoking in the next 30 days
- Current regular use of other nicotine products
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