An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas



Status:Recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:15 - Any
Updated:9/27/2018
Start Date:December 18, 2015
End Date:February 13, 2020
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

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A Phase I/ II Study to Evaluate the Safety and Preliminary Efficacy of Nivolumab in Combination With Brentuximab Vedotin in Subjects With Relapsed Refractory Non Hodgkin Lymphomas With CD30 Expression (CheckMate 436: CHECKpoint Pathway and Nivolumab Clinical Trial Evaluation 436)

The purpose of this study is to determine whether Nivolumab, in combination with brentuximab
vedotin, is safe and effective in patients with certain subtypes of non-Hodgkin's lymphomas
with CD30 expression that have not responded to treatment or have come back. The subtypes we
are studying are Diffuse Large B-Cell Lymphoma (DLBCL), Peripheral T-Cell Lymphoma (PTCL),
Cutaneous T-Cell Lymphoma (CTCL), Primary Mediastinal Large B-Cell Lymphoma (PMBL) and
Mediastinal Gray Zone Lymphoma (MGZL).


For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- Relapsed/refractory diffuse large B cell lymphoma (DLBCL), relapsed/refractory
peripheral T cell lymphoma (PTCL) (all subtypes excluding anaplastic large cell
lymphoma), relapsed/refractory Cutaneous T cell lymphoma (CTCL) mycosis
fungoides/sezary syndrome (MF/SS), relapsed/refractory primary mediastinal B lymphoma
(PMBL), and relapsed/refractory mediastinal gray zone lymphoma (MGZL)

- Expression of CD30

- Subjects must be 18 years or older (≥ 15 years for PMBL)

Exclusion Criteria:

- Known central nervous system (CNS) lymphomas; Active cerebral/meningeal disease
related to the underlying malignancy

- Active, known, or suspected autoimmune disease
We found this trial at
18
sites
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Phone: 585-276-8333
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Phone: 205-975-2076
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Phone: 773-702-0342
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Phone: 503-216-3067
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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Portland, OR
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Phone: 206-288-6787
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, WA
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Atlanta, Georgia 30322
Phone: 404-778-3935
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Atlanta, GA
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Charlotte, North Carolina 28211
Phone: 980-442-2011
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Charlotte, NC
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Columbus, Ohio 43210
Phone: 614-366-0855
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Columbus, OH
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Greenville, South Carolina 29601
Phone: 864-546-3699
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Greenville, SC
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Hackensack, New Jersey 07601
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Hackensack, NJ
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1475 NW 12th Ave
Miami, Florida 33136
(305) 243-1000
Phone: 305-243-7648
University of Miami, Sylvester Comprehensive Cancer Center Sylvester Comprehensive Cancer Center integrates all cancer-related activities...
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Miami, FL
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1428 Madison Ave
New York, New York 10029
(212) 241-6500
Phone: 212-824-8583
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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New York, NY
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 212-639-4839
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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Oklahoma City, Oklahoma 73104
Phone: 405-271-4022
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Oklahoma City, OK
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Rochester, Minnesota 55905
Phone: 507-284-0923
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Rochester, MN
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-747-8064
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Tampa, Florida 33612
Phone: 813-745-1706
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Vancouver, British Columbia
Phone: 60487760002738
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