Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

Conditions:Psychiatric, Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Age Range:18 - 65
Start Date:October 2015
End Date:August 2020
Contact:Melanie Jefferson, MS

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Post-Traumatic Stress Disorder and Cardiovascular Disease Risk: Role of Sympathetic Overactivity and Angiotensin II

The purpose of this study is to find out why patients with post-traumatic stress disorder
(PTSD) have an increased risk for heart disease and high blood pressure later in life. A
second purpose is to find out what causes PTSD patients to have high adrenaline levels during
stress. This study will also test if a medicine called losartan improves high adrenaline
levels in patients with PTSD and if a certain gene that has to do with high blood pressure
might be associated with high adrenaline levels.

Inclusion Criteria:

- veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age,
gender, and race.

Exclusion Criteria:

- pregnancy

- hypertension

- diabetes

- heart or vascular disease

- illicit drug use

- excessive alcohol use (>2 drinks per day)

- hyperlipidemia

- autonomic dysfunction

- current treatment with clonidine, beta blockers, angiotensin-converting-enzyme (ACE)
inhibitors, or angiotensin II receptor blockers (ARBs)

- treatment with monoamine oxidase (MAO) inhibitors within the last 14 days

- any serious systemic disease

- chronic kidney disease defined as estimated glomerular filtration rate (GFR) < 60

- hyperkalemia (serum potassium > 5 meq/dL)

- systolic blood pressure < 100 mm Hg

- diastolic blood pressure < 60 mm Hg

- heart rate < 50 beats/min

- known hypersensitivity to ARBs or beta blockers
We found this trial at
Decatur, Georgia 30033
Principal Investigator: Jeanie Park, MD
Phone: 404-321-6111
Decatur, GA
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