Validation of Edema-invariant Multi-shell High Angular Resolution Diffusion Imaging (msHARDI)-Based Tractography With Intra-operative Cortical Stimulation



Status:Recruiting
Healthy:No
Age Range:18 - 80
Updated:11/2/2018
Start Date:June 2014
End Date:June 2020
Contact:Steven Brem, MD
Email:PennCancertrials@emeringmed.com
Phone:855-216-0098

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Currently, standard-of-care tractography is based on information obtained from diffusion
tensor imaging (DTI). DTI is a diffusion magnetic resonance imaging (dMRI) technique that is
routinely obtained on neurosurgical patients to assist in pre-operative planning. The primary
objective of the proposed study is to determine the ability of msHARDI-based tractography to
discern fibers in edematous brain regions.


Inclusion Criteria:

- brain lesions, including but not limited to tumors, epileptic foci, and vascular
abnormalities, in or around eloquent brain regions (i.e., motor, language);

- clinical need for pre-operative 'advanced imaging' (which includes conventional DTI);

- age between 18-80 years of age;

- male or female gender. Eloquent regions include: Temporal and frontal lobes
(speech/language); bilateral occipital lobes (vision); bilateral parietal lobes
(sensation); and bilateral motor cortex (movement).

Exclusion Criteria:

- a contraindication for obtaining an MRI scan (e.g. implanted devices, retrained
foreign body)

- pregnancy

- absence of the capacity to make medical decisions or provide informed consent.
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
(215) 662-6065
Principal Investigator: Steven Brem, MD
Phone: 215-614-0458
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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Philadelphia, PA
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