Assessment of the Tolerability of Dry Airflow in the Nasal Cavity During Sleep
| Status: | Withdrawn |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 8/9/2017 |
| Start Date: | January 2015 |
| End Date: | January 2018 |
Preliminary data show that high flow nasal air has been shown to reduce promote heat exchange
due to evaporation of nasal mucus by the air flow resulting in heat loss. It is unclear
whether unidirectional nasal airflow is well tolerated in healthy individuals. The central
hypothesis of this proposal is that dry high flow nasal air will be sufficiently tolerated in
healthy adults.
due to evaporation of nasal mucus by the air flow resulting in heat loss. It is unclear
whether unidirectional nasal airflow is well tolerated in healthy individuals. The central
hypothesis of this proposal is that dry high flow nasal air will be sufficiently tolerated in
healthy adults.
Inclusion Criteria:
- Healthy men and women
- Able to consent
- Age ≥ 18
- BMI<30kg/m2
Exclusion Criteria:
- Previous diagnosis of obstructive sleep apnea or sleep disorder
- History of Constant Positive Airway Pressure treatment for Obstructive Sleep Apnea
- History of recurrent epistasis
- Pregnancy (self-report)
- Deviated nasal septum
- Unstable cardiovascular disease (decompensated Congestive Heart Failure, myocardial
infarction or revascularization procedures, unstable arrhythmias)
- Uncontrolled hypertension with BP > 190/110
- Daytime hypoxemia with oxygen saturation<90% (measured at history and physical
examination)
- Supplemental oxygen use
- Work in transportation industry as a driver or pilot.
We found this trial at
1
site
3400 N Charles St
Baltimore, Maryland 21205
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Jason Kirkness, PhD
Phone: 410-550-2184
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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