Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients



Status:Recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 80
Updated:10/17/2018
Start Date:July 2015
End Date:May 2019
Contact:Cathrin Buetefisch
Email:cathrin.buetefisch@emory.edu
Phone:4047121894

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The purpose of this study is to identify and establish how the area of the brain that
controls motor function (motor cortex) might serve as a new focus for treatment for stroke.
The therapeutic intervention aims to identify protocols that improve motor performance after
stroke.


Inclusion Criteria:

- The ability to provide informed consent

- Ages 50 to 80 years old

- Male or female

Stroke Patients

- One cerebral ischemic infarction less than 1 month affecting the primary motor output
system of the hand at a cortical (M1) level as defined by magnetic resonance imaging
(MRI) of the brain

- Paresis of the hand for more than 3 days after their cerebral infarction

- Extension of the wrist (medical research council scale for assessment of muscle power
score of at least 3 and greater than 10 degrees) at the time of the enrollment into
the study

Healthy Subjects

- Normal MRI of the brain

- Normal neuropsychological testing

- Normal neurological examination

Exclusion Criteria:

Stroke Patients

- Neurological disorders other than stroke

- Aphasia that prevents following instructions or inability to communicate effectively
with the study team

- Dementia

- Moderate or severe depression

- Contraindication to transcranial magnetic stimulation (TMS) and/or MRI

- Use of central nervous system (CNS) active drugs that block plasticity

Healthy Subjects

- Neurological Disease

- Psychiatric Disease

- Use of CNS active drugs

- Contraindication to TMS
We found this trial at
3
sites
1648 Pierce Dr NE
Atlanta, Georgia 30322
(404) 727-5640
Principal Investigator: Cathrin Buetefisch, MD, PhD
Phone: 678-369-3152
Emory University School of Medicine Emory University School of Medicine has 2,359 full- and part-time...
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Atlanta, Georgia 30322
Phone: 404-712-1894
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Atlanta, GA
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1364 Clifton Rd NE
Atlanta, Georgia 30322
(404) 712-2000
Phone: 404-712-5507
Emory University Hospital As the largest health care system in Georgia and the only health...
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Atlanta, GA
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